Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy

Hossein S. Yazdi; Thomas D. O'Sullivan; Anaïs Leproux; Brian Hill; Amanda Durkin; Seraphim Telep; Jesse Lam; Siavash S. Yazdi; Alice M. Police; Robert M. Carroll; Freddie J. Combs; Tomas Strömberg; Arjun G. Yodh; Bruce J. Tromberg

doi:10.1117/1.JBO.22.4.045003

5 April 2017 Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy

Hossein S. Yazdi, Thomas D. O'Sullivan, Anaïs Leproux, Brian Hill, Amanda Durkin, Seraphim Telep, Jesse Lam, Siavash S. Yazdi, Alice M. Police, Robert M. Carroll, Freddie J. Combs, Tomas Strömberg, Arjun G. Yodh, Bruce J. Tromberg

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Journal of Biomedical Optics, Vol. 22, Issue 4, 045003 (April 2017). https://doi.org/10.1117/1.JBO.22.4.045003

Abstract

Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, μa, and reduced scattering, μs′) and blood flow (blood flow index, BFI), respectively. DOSI-derived μa values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin (HbO2, HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 mm−1 (37%) in μs′ and 0.003 mm−1 (33%) in μa lead to ∼53% and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and

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Hossein S. Yazdi, Thomas D. O'Sullivan, Anaïs Leproux, Brian Hill, Amanda Durkin, Seraphim Telep, Jesse Lam, Siavash S. Yazdi, Alice M. Police, Robert M. Carroll, Freddie J. Combs, Tomas Strömberg, Arjun G. Yodh, and Bruce J. Tromberg "Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy," Journal of Biomedical Optics 22(4), 045003 (5 April 2017). https://doi.org/10.1117/1.JBO.22.4.045003

Received: 23 November 2016; Accepted: 13 March 2017; Published: 5 April 2017

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