Real-time in vivo color Doppler optical coherence tomography

Andrew M. Rollins; Siavash Yazdanfar; Jennifer Kehlet Barton; Joseph A. Izatt

doi:10.1117/1.1428291

1 January 2002 Real-time in vivo color Doppler optical coherence tomography

Andrew M. Rollins, Siavash Yazdanfar, Jennifer Kehlet Barton, Joseph A. Izatt

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Journal of Biomedical Optics, Vol. 7, Issue 1, (January 2002). https://doi.org/10.1117/1.1428291

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissuesimulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.

©(2002) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Andrew M. Rollins, Siavash Yazdanfar, Jennifer Kehlet Barton, and Joseph A. Izatt "Real-time in vivo color Doppler optical coherence tomography," Journal of Biomedical Optics 7(1), (1 January 2002). https://doi.org/10.1117/1.1428291

Published: 1 January 2002

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