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1 October 2002 Charge transfer fluorescent probes using boronic acids for monosaccharide signaling
Nicholas DiCesare, Joseph R. Lakowicz
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Journal of Biomedical Optics, Vol. 7, Issue 4, (October 2002). https://doi.org/10.1117/1.1502263
We have developed a new series of glucose sensitive fluorophores that display shifts in emission wavelengths and/or intensity change upon the binding of monosaccharides. Complexation of glucose with the boronic acid moiety changes both its orbital hybridization and its ability to accept and donate electrons. This change results in distinct emission spectra for the fluorophores when free in solution or complexed with monosaccharide. The spectral changes upon saccharide binding can be modified by substitution of electron donor or acceptor group on the fluorophore allowing rational design of the spectral response.
©(2002) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Nicholas DiCesare and Joseph R. Lakowicz "Charge transfer fluorescent probes using boronic acids for monosaccharide signaling," Journal of Biomedical Optics 7(4), (1 October 2002). https://doi.org/10.1117/1.1502263
Published: 1 October 2002
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Cited by 34 scholarly publications and 2 patents.
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KEYWORDS
Glucose
Luminescence
Electrons
Boron
Blood
Fluorescence spectroscopy
Spectroscopy
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