Review of optical detection of single molecules beyond the diffraction and diffusion limit using plasmonic nanostructures

Farzia Karim; Todd B. Smith; Chenglong Zhao

doi:10.1117/1.JNP.12.012504

22 June 2017 Review of optical detection of single molecules beyond the diffraction and diffusion limit using plasmonic nanostructures

Farzia Karim, Todd B. Smith, Chenglong Zhao

Author Affiliations +

Journal of Nanophotonics, Vol. 12, Issue 1, 012504 (June 2017). https://doi.org/10.1117/1.JNP.12.012504

Abstract

Single-molecule detection has become a unique and indispensable tool for the study of molecular motions and interactions at the single-molecule level. Unlike ensemble measurement where the information is averaged, single-molecule analysis yields invaluable information on both the individual molecular properties and their microenvironment. Among the various technologies for the detection of single molecules, the detection with optical methods has many advantages in terms of its high sensitivity, electrical passiveness, and robustness. The recent advances in the engineering of either the excitation light or the solution of the molecules have paved the way for enhanced single-molecule detection. We present recent developments and future perspectives for single-molecule detection in the following three regimes: on a dry surface, in solutions at ultralow concentrations, and in solutions at native physiological concentrations.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Farzia Karim, Todd B. Smith, and Chenglong Zhao "Review of optical detection of single molecules beyond the diffraction and diffusion limit using plasmonic nanostructures," Journal of Nanophotonics 12(1), 012504 (22 June 2017). https://doi.org/10.1117/1.JNP.12.012504

Received: 19 April 2017; Accepted: 5 June 2017; Published: 22 June 2017

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Cited by 11 scholarly publications.

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KEYWORDS

Molecules

Diffraction

Diffusion

Nanostructures

Plasmonics

Singular optics

Molecular interactions

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