We provide an optimized closed-loop algorithm for color control of a multichannel light-emitting diode (LED) lighting system using a multispectral sensor. The proposed control scheme makes it possible to maintain a desired lighting ambience in a room by taking into account external lighting sources. It rejects disturbances specific to LEDs (spectral drift) or independent from them (variations in external lighting, changes in the room access conditions, or changes in the lighting inside the room such as a light addition). This control scheme consists of using a multispectral sensor, a regulator, an anti-windup system, an efficient optimization algorithm, and a set of colored LEDs. Experimental results show the high performance of a preindustrial system with a color difference Δu^′v^′  =  0.0004. This value is below the threshold of the color difference that is considered noticeable by the human eye.