Improvement of decorrelation-based OCT angiography by an adaptive spatial-temporal kernel in monitoring stimulus-evoked hemodynamic responses

Ruixiang Chen; Lin Yao; Kaiyuan Liu; Tongtong Cao; Huakun Li; Peng Li

doi:10.1117/12.2577517

5 March 2021 Improvement of decorrelation-based OCT angiography by an adaptive spatial-temporal kernel in monitoring stimulus-evoked hemodynamic responses

Ruixiang Chen, Lin Yao, Kaiyuan Liu, Tongtong Cao, Huakun Li, Peng Li

Author Affiliations +

Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410E (2021) https://doi.org/10.1117/12.2577517
Event: SPIE BiOS, 2021, Online Only

Abstract

Complex decorrelation-based OCT angiography (OCTA) has the potential for quantitively monitoring hemodynamic activities. To improve the dynamic range and uncertainty for quantification, an adaptive spatial-temporal (ST) kernel was proposed. The ensemble size in decorrelation computation was enlarged by collecting samples in the spatial/ temporal dimensions. The spatial sub-kernel size was adaptively changed to suppress the bulk motion influence by solving a maximum entropy model. The improvement of dynamic range and uncertainty were validated by theoretical analyzation, numerical simulation, and in vitro/ in vivo experiments. Furthermore, proved by the in vivo experiments, the adaptive ST-kernel can also improve the separability between different stimuli and allow a reliable temporal analysis of the hemodynamic response.

Conference Presentation

Citation Download Citation

Ruixiang Chen, Lin Yao, Kaiyuan Liu, Tongtong Cao, Huakun Li, and Peng Li "Improvement of decorrelation-based OCT angiography by an adaptive spatial-temporal kernel in monitoring stimulus-evoked hemodynamic responses", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410E (5 March 2021); https://doi.org/10.1117/12.2577517

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Hemodynamics

Angiography

Optical coherence tomography

Blood circulation

Motion analysis

Motion models

Numerical simulations

Keywords/Phrases

Search In:

Publication Years