Measuring mechanical anisotropy of the cornea with Brillouin microscopy

Amira M. Eltony; Peng Shao; Seok-Hyun Yun

doi:10.1117/12.2584263

5 March 2021 Measuring mechanical anisotropy of the cornea with Brillouin microscopy

Amira M. Eltony, Peng Shao, Seok-Hyun Yun

Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 1164517 (2021) https://doi.org/10.1117/12.2584263
Event: SPIE BiOS, 2021, Online Only

Abstract

Anisotropic mechanical properties are a feature of many load-bearing tissues, such as muscles or blood vessel walls, which typically contain preferentially oriented collagen or elastin fibers embedded in a hydrated matrix. Measuring the anisotropy on a microstructural scale is important for modeling tissues' mechanical response, but has been difficult to obtain noninvasively. Here, we employ Brillouin microscopy to characterize the anisotropy of corneal tissues. We use angle-resolved Brillouin measurements to determine the longitudinal moduli of the ex vivo porcine cornea, assuming a lamellar, transverse isotropic model. We also observe significant anisotropy in Brillouin maps of the human cornea in vivo.

Conference Presentation

Citation Download Citation

Amira M. Eltony, Peng Shao, and Seok-Hyun Yun "Measuring mechanical anisotropy of the cornea with Brillouin microscopy", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 1164517 (5 March 2021); https://doi.org/10.1117/12.2584263

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