Strategies for the development of photonic sensors for COVID-19

Benjamin L. Miller; Alanna M. Klose; Michael R. Bryan; John S. Cognetti; Daniel J. Steiner; Natalya Tokranova; Brian Piorek; Nicholas Judy; Minhaz Abedin; Ethan Young; Carl Meinhart; Raymond Jakubowicz; Harold Warren; Nathaniel C. Cady

doi:10.1117/12.2616682

2 March 2022 Strategies for the development of photonic sensors for COVID-19

Benjamin L. Miller, Alanna M. Klose, Michael R. Bryan, John S. Cognetti, Daniel J. Steiner, Natalya Tokranova, Brian Piorek, Nicholas Judy, Minhaz Abedin, Ethan Young, Carl Meinhart, Raymond Jakubowicz, Harold Warren, Nathaniel C. Cady

Author Affiliations +

Proceedings Volume 11951, Design and Quality for Biomedical Technologies XV; 1195104 (2022) https://doi.org/10.1117/12.2616682
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Beyond the optical and analytical performance of the sensor itself, the development of an optical detection tool in response to a pressing research or diagnostic need requires consideration of a host of additional factors. This talk will provide an overview of two photonic sensor systems developed for profiling the human immune response to COVID-19 infection and/or vaccination. One, focused on the design goal of high multiplexing (many targets per sensor), was built on the Arrayed Imaging Reflectometry (AIR) platform. AIR is a free-space optics technique that relies on the creation and target molecule binding-induced disruption of an antireflective coating on the surface of a silicon chip. The second method, focused on low cost and high speed, uses a small (1 x 4 mm) ring resonator photonic chip embedded in a plastic card able to provide passive transport of human samples. This “disposable photonics” platform is able to detect and quantify anti-COVID antibodies in a human sample in a minute, making it attractive for high-throughput testing applications.

Conference Presentation

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Benjamin L. Miller, Alanna M. Klose, Michael R. Bryan, John S. Cognetti, Daniel J. Steiner, Natalya Tokranova, Brian Piorek, Nicholas Judy, Minhaz Abedin, Ethan Young, Carl Meinhart, Raymond Jakubowicz, Harold Warren, and Nathaniel C. Cady "Strategies for the development of photonic sensors for COVID-19", Proc. SPIE 11951, Design and Quality for Biomedical Technologies XV, 1195104 (2 March 2022); https://doi.org/10.1117/12.2616682

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