A novel fiber-optic surface plasmon resonance sialic acid nanosensor based on boronic-acid-functionalized Au NPs

Huizhen Yuan; Shuwen Chu; Guangyi Sun; Na Li; Wei Peng

doi:10.1117/12.2606870

1 November 2021 A novel fiber-optic surface plasmon resonance sialic acid nanosensor based on boronic-acid-functionalized Au NPs

Huizhen Yuan, Shuwen Chu, Guangyi Sun, Na Li, Wei Peng

Author Affiliations +

Proceedings Volume 12057, Twelfth International Conference on Information Optics and Photonics; 1205748 (2021) https://doi.org/10.1117/12.2606870
Event: Twelfth International Conference on Information Optics and Photonics, 2021, Xi'an, China

Abstract

Sialic acid (SA) exists as a sialic acid complex and participates in a variety of important physiological functions of the body, such as cell recognition. The increase in the concentration of sialic acid in human biological samples exceeds the normal concentration and is related to the development of various cancers. The SPR based label-free detection of small targeted molecules is a great challenge and require substantial signal amplification for the accurate and precise quantification. We have developed an SA sensor based on boric acid fiber-optic SPR in the form of Sialic acid. The signal enhancement technology of 4-mercaptophenylboronic acid (MPBA) modified gold nanoprobe is used for the high-sensitivity detection of sialic acid. Under optimal conditions, the SA concentration has a linear relationship between 0.0001 and 1 mM. The detection limit reached 100 nM. Fiber-based SPR sensing technology not only has high sensitivity and detection, but also avoids damage to biological samples, which has a wide range of application potential in biological non-destructive sensing.

Citation Download Citation

Huizhen Yuan, Shuwen Chu, Guangyi Sun, Na Li, and Wei Peng "A novel fiber-optic surface plasmon resonance sialic acid nanosensor based on boronic-acid-functionalized Au NPs", Proc. SPIE 12057, Twelfth International Conference on Information Optics and Photonics, 1205748 (1 November 2021); https://doi.org/10.1117/12.2606870

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KEYWORDS

Gold

Fiber optics

Sensors

Signal detection

Fiber optics sensors

Nanoparticles

Optical fibers

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