Intraoperative monitoring CBF dynamics during MCAO by laser speckle contrast imaging

Yi Chang; Liangwei Meng; Yiqian Wang; Mange Huang; Peian Xiao; Jinling Lu; Pengcheng Li

doi:10.1117/12.2682695

18 July 2023 Intraoperative monitoring CBF dynamics during MCAO by laser speckle contrast imaging

Yi Chang, Liangwei Meng, Yiqian Wang, Mange Huang, Peian Xiao, Jinling Lu, Pengcheng Li

Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 127450Q (2023) https://doi.org/10.1117/12.2682695
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China

Abstract

The intraluminal filament Middle Cerebral Artery Occlusion (MCAO) model is widely used to study animal models of cerebral ischemia. Laser Speckle Contrast Imaging (LSCI) provides an approach to monitor changes in cortical Cerebral Blood Flow (CBF) in mice through intact skull. However, the MCAO surgery requires a supine position of animals during preparation, where the conventional LSCI systems cannot achieve to provide a real-time high spatio-temporal resolution CBF information. Herein, we implemented an optimized method to uninterruptedly measure the relative CBF during surgical procedures by designing an inverted LSCI (i-LSCI). This approach achieves a real-time high spatio-temporal resolution CBF information during the MCAO surgery, enabling a real-time monitoring of cerebral collateral circulation and assessment of the stability of the ischemic site immediately after MCAO. Moreover, this optimization allows for a detection of Cortical Spreading Depolarization (CSD) in ischemic cortex immediately after MCAO.

Citation Download Citation

Yi Chang, Liangwei Meng, Yiqian Wang, Mange Huang, Peian Xiao, Jinling Lu, and Pengcheng Li "Intraoperative monitoring CBF dynamics during MCAO by laser speckle contrast imaging", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 127450Q (18 July 2023); https://doi.org/10.1117/12.2682695

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KEYWORDS

Laser speckle contrast imaging

Simulation of CCA and DLA aggregates

Surgery

Arteries

Ischemia

Animal model studies

Animals

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