Characterization of the hydration state of pharmaceuticals by variable-temperature diffuse-reflectance infrared spectroscopy

Frank M. Wasacz; Scott W. Strand; David E. Bugay; Kenneth R. Morris

doi:10.1117/12.56324

1 March 1992 Characterization of the hydration state of pharmaceuticals by variable-temperature diffuse-reflectance infrared spectroscopy

Frank M. Wasacz, Scott W. Strand, David E. Bugay, Kenneth R. Morris

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Proceedings Volume 1575, 8th Intl Conf on Fourier Transform Spectroscopy; (1992) https://doi.org/10.1117/12.56324
Event: Eighth International Conference on Fourier Transform Spectroscopy, 1991, Lubeck-Travemunde, Germany

Abstract

The characterization of hydrates is exceedingly important for pharmaceuticals since the state of hydration of a drug can effect its solubility, dissolution rate, bioavailability, chemical stability, and the physical stability of subsequent dosage forms. In addition, the United States Food and Drug Administration concerns about the above issue make complete characterization of hydrates a necessary part of investigative new drug filings. A Collector TM Diffuse Reflectance accessory fitted with a controlled Environmental Chamber was used to study drug formulations under varying temperature and humidity conditions.

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Frank M. Wasacz, Scott W. Strand, David E. Bugay, and Kenneth R. Morris "Characterization of the hydration state of pharmaceuticals by variable-temperature diffuse-reflectance infrared spectroscopy", Proc. SPIE 1575, 8th Intl Conf on Fourier Transform Spectroscopy, (1 March 1992); https://doi.org/10.1117/12.56324

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