Light emitting diode (LED) system for photodynamic therapy

Greg Graham; A. Charles Lytle; Brian K. Dalton; Dale D. Severson; Jon A. Warner; Greta M. Garbo; Greg B. Rocklin; Daniel R. Doiron

doi:10.1117/12.208175

1 May 1995 Light emitting diode (LED) system for photodynamic therapy

Greg Graham, A. Charles Lytle, Brian K. Dalton, Dale D. Severson, Jon A. Warner, Greta M. Garbo, Greg B. Rocklin, Daniel R. Doiron

Author Affiliations +

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208175
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Photodynamic therapy, PDT, has mainly been done clinically using laser systems. The use of lasers to treat cutaneous lesions is not necessary. In order to provide a more efficient and cost effective light source for the PDT treatment of cutaneous lesions, a clinical based light emitting diode (LED) system has been developed. The system include a tight density packing of AlGaAs high-brightness LEDs to produce incident irradiance values up to 200 MW/cm². Initial systems have wavelengths of 665 nm and exhibit a bandwidth of 25 nm, FWHM. Other wavelengths are also possible. The system includes on-line dosimetry through an isotropic probe to permit the use to simply choose a dose, J/cm². the system has been tested against a KTP/dye laser for the photosensitizer SnET2 to determine its equivalence to a monochromatic source.

Citation Download Citation

Greg Graham, A. Charles Lytle, Brian K. Dalton, Dale D. Severson, Jon A. Warner, Greta M. Garbo, Greg B. Rocklin, and Daniel R. Doiron "Light emitting diode (LED) system for photodynamic therapy", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208175

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