Novel LED array used for photodynamic therapy (PDT)

Steven R. Daly; Frank Zheng; Mike Krouse; Zihong Guo; Paula Mahoney; Brian W. McIlroy

doi:10.1117/12.480155

3 July 2003 Novel LED array used for photodynamic therapy (PDT)

Steven R. Daly, Frank Zheng, Mike Krouse, Zihong Guo, Paula Mahoney, Brian W. McIlroy

Proceedings Volume 4996, Light-Emitting Diodes: Research, Manufacturing, and Applications VII; (2003) https://doi.org/10.1117/12.480155
Event: Integrated Optoelectronics Devices, 2003, San Jose, CA, United States

Abstract

Light Sciences Corporation has developed a novel LED array that was designed and manufactured to treat large bulky tumors. We describe our LED design process, culminating in the manufacture of a flexible silicone catheter currently under investigation in a Phase 1 clinical trial. The performance characteristics of the wire-bonded die to a flexible polyimide substrate forming a linear array are discussed. The LED array consists of 100 die arranged asymmetrically on the substrate with 50 LED's on either side producing up to 60mW total optical power at 38°C (500mA) over a spectral bandwidth 645-670nm FWHM. The LED's are encapsulated within biocompatible silicon for interstitial placement within the treatment tissue. The effect of time, temperature and humidity on the device performance was investigated. Optical power ranged from −2.5% to +0.5% of the normalized original power over 50 hours in 100% RH within the control group. Over a temperature range of 35°C to 50°C the optical power decreased at a rate of 0.56% per °C. Preliminary non-clinical experiments carried out in normal swine muscle demonstrate a significant treatment zone and are consistent with threshold models for photodynamic effect.

Citation Download Citation

Steven R. Daly, Frank Zheng, Mike Krouse, Zihong Guo, Paula Mahoney, and Brian W. McIlroy "Novel LED array used for photodynamic therapy (PDT)", Proc. SPIE 4996, Light-Emitting Diodes: Research, Manufacturing, and Applications VII, (3 July 2003); https://doi.org/10.1117/12.480155

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