Synthesis and properties of new chlorin and bacteriochlorin photosensitizers

Andrei F. Mironov

doi:10.1117/12.230970

31 January 1996 Synthesis and properties of new chlorin and bacteriochlorin photosensitizers

Andrei F. Mironov

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230970
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

A series of novel sensitizers, which absorb in the range of 660 - 820 nm, derived from natural occurring chlorophyll and bacteriochlorophyll was synthesized. Biomass of blue-green algae Spirulina platensis was used to prepare chlorophyll a derivatives, and biomass of purple bacteria Rhodobacter capsulatus was applied for preparation of bacteriochlorophyll a. The influence of different substituents on spectral characteristics and the amphipility of the sensitizer was investigated. The route for the synthesis of porphyrin macrocycle with the spacer that bears the isothiocyanate group capable for binding with proteins was proposed. Photophysical properties of chlorin p₆, purpurin 18 and their esters in different solvents are investigated. Accumulation of two chlorins in the model Erlich tumor was studied.

Citation Download Citation

Andrei F. Mironov "Synthesis and properties of new chlorin and bacteriochlorin photosensitizers", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230970

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