Optimization of low-coherence interferometry for quantitative analysis of tissue optical properties

Alexander I. Kholodnykh; Irina Y. Petrova; Kirill V. Larin; Massoud Motamedi; Rinat O. Esenaliev

doi:10.1117/12.468325

23 May 2002 Optimization of low-coherence interferometry for quantitative analysis of tissue optical properties

Alexander I. Kholodnykh, Irina Y. Petrova, Kirill V. Larin, Massoud Motamedi, Rinat O. Esenaliev

Proceedings Volume 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II; (2002) https://doi.org/10.1117/12.468325
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Noninvasive monitoring of analytes can be performed with optical coherence tomography (OCT) technique. This technique may allow measurement of optical properties of tissue (attenuation, scattering, optical thickness, etc.) that may be dependent on analyte concentration. Accurate monitoring of analyte concentration requires measurement of the optical properties with high accuracy. The accuracy of measurements depends on OCT technical characteristics and the level of speckle noise. In this paper, we report the results of the calibration of OCT system sensitivity for absolute and relative measurements of the backscattering and total attenuation coefficients in scattering standard, tissue phantoms (suspensions of polystyrene microspheres in water solutions of glucose), and human skin. We measured the OCT sensitivity as a function of depth and used this dependence for correction of signals. The amplitude and spatial period of backscattered signal modulation resulted from speckle noise were measured for the scattering standard and human skin. The dependence of speckle and electronic noise on the range of spatial and temporal averaging of OCT signals was determined. Our studies show that the accuracy of measurement of changes in optical properties of tissue with OCT technique can be significantly improved by reducing of speckle noise and by using the signal correction algorithm.

Citation Download Citation

Alexander I. Kholodnykh, Irina Y. Petrova, Kirill V. Larin, Massoud Motamedi, and Rinat O. Esenaliev "Optimization of low-coherence interferometry for quantitative analysis of tissue optical properties", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); https://doi.org/10.1117/12.468325

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