Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma

Hongbin Wang; Baoxu Huang; Huanqi Liu; Zhina Qu; Xifeng Liu; Shaohui Cheng

doi:10.1117/12.572054

29 July 2004 Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma

Hongbin Wang, Baoxu Huang, Huanqi Liu, Zhina Qu, Xifeng Liu, Shaohui Cheng

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Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572054
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

By using the experimental model of mouse S180 ascites sarcoma, the feasibility and mechanism of low-energy laser therapy combined with the traditional antitumor drug of cyclophosphamide in the treatment of malignant tumors were discussed. The S180 ascites sarcoma suffering BALB/c mice were irradiated upon the Harder's glands with the dosages of 11.00, 14.67 and 22.00 J/cm² respectively, and/or injected with CYT intraperitoneally to evaluate the therapeutic effects of CYT/LELT combination on malignant tumors. The three dosages of LELT combined with CYT all showed remarkably therapeutic effects on the mouse S180 ascites sarcoma. Comparatively, the dosage of 14.67J/cm² LELT combined with CYT showed the most ideal therapeutic effects and the survival time was up to 20.80 days, and the life prolongation ratio was 33.33% which was remarkably higher than those of the CYT and tumor control groups. CYT/LELT combined therapy had remarkably inhibiting effects on the mice ascites growth because of the existence of CYT.

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Hongbin Wang, Baoxu Huang, Huanqi Liu, Zhina Qu, Xifeng Liu, and Shaohui Cheng "Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572054

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KEYWORDS

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Laser therapeutics

Silicon

Laser irradiation

Agriculture

Tumor growth modeling

Animal model studies

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