Monte Carlo simulation of elastic-scattering spectroscopic measurement using the optical pharmacokinetic system (OPS): analysis of sensitivity to heterogeneous chromophore distribution

Stephen Chad Kanick; Robert S. Parker

doi:10.1117/12.699137

28 February 2007 Monte Carlo simulation of elastic-scattering spectroscopic measurement using the optical pharmacokinetic system (OPS): analysis of sensitivity to heterogeneous chromophore distribution

Stephen Chad Kanick, Robert S. Parker

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 642710 (2007) https://doi.org/10.1117/12.699137
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Effective photodynamic therapy depends on an adequate supply of photosensitizer, oxygen, and light fluence. During light exposure, the rapid depletion of molecular oxygen within tissue can lead to the development of hypoxic regions, which decreases the generation of reactive oxygen species and can result in non-uniform tissue necrosis. The Optical Pharmacokinetic System (OPS) is a fiber-optic based spectroscopy device that may be able to monitor local tissue oxygen concentrations during treatment and identify problematic hypoxic regions in vivo. However, the 'bulk' signal detected by the OPS is potentially limited in its ability to discern the development of small hypoxic regions within tissue. This study employs a Monte Carlo simulation of the elastically-scattered light as measured by the OPS to investigate the effect of heterogeneous chromophore distributions on the detected signal. The model tissue geometry is constructed to mimic tissue in vivo, with discrete capillaries interspersed throughout. Tissue optical properties are specified spatially, allowing investigation of heterogeneous chromophore distribution. Simulations investigate the effect that discrete, highly absorbing regions within a measured sample have on the light collected by the OPS. Simulations also consider OPS measurement of a sample with a depth-dependent chromophore concentration gradient and quantitate the ability of the OPS to detect the presence of a sub-population of hypoxic vessels within a network of oxygenated vessels.

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Stephen Chad Kanick and Robert S. Parker "Monte Carlo simulation of elastic-scattering spectroscopic measurement using the optical pharmacokinetic system (OPS): analysis of sensitivity to heterogeneous chromophore distribution", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 642710 (28 February 2007); https://doi.org/10.1117/12.699137

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KEYWORDS

Tissue optics

Absorption

Tissues

Signal detection

Chromophores

Monte Carlo methods

Blood vessels

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