Near-infrared optical tomography: endoscopic imaging approach

Daqing Piao; Hao Xie; Cameron Musgrove; Charles F. Bunting; Weili Zhang; Guolong Zhang; Ellen B. Domnick-Davidsion; Kenneth Eugene Bartels D.V.M.; G. Reed Holyoak; Sreenivas N. Vemulapalli; Hamid Dehghani; Brian W. Pogue

doi:10.1117/12.695217

20 February 2007 Near-infrared optical tomography: endoscopic imaging approach

Daqing Piao, Hao Xie, Cameron Musgrove, Charles F. Bunting, Weili Zhang, Guolong Zhang, Ellen B. Domnick-Davidsion, Kenneth Eugene Bartels D.V.M., G. Reed Holyoak, Sreenivas N. Vemulapalli, Hamid Dehghani, Brian W. Pogue

Author Affiliations +

Proceedings Volume 6431, Multimodal Biomedical Imaging II; 643103 (2007) https://doi.org/10.1117/12.695217
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Near-infrared optical tomography is an interesting technique of imaging with high blood-based contrast. Unfortunately non-invasive NIR tomographic imaging has been restricted to specific organs like breast that can be transilluminated externally. In this paper, we demonstrate that near-infrared (NIR) optical tomography can be employed at the endoscope-scale, and implemented at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source is combined with light delivery by linear-to-circular fiber bundle, to provide endoscopic probing of multiple source/detector fibers for tomographic imaging as well as parallel sampling of all source-detector pairs for rapid data acquisition. Endoscopic NIR tomography is demonstrated by use of a 12mm diameter probe housing 8 sources and 8 detectors at 8 Hz frame rate. Transrectal NIR optical tomography by use of tissue specimen is also presented. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be tried in cancer detection of internal organs via endoscopic interrogation.

Citation Download Citation

Daqing Piao, Hao Xie, Cameron Musgrove, Charles F. Bunting, Weili Zhang, Guolong Zhang, Ellen B. Domnick-Davidsion, Kenneth Eugene Bartels D.V.M., G. Reed Holyoak, Sreenivas N. Vemulapalli, Hamid Dehghani, and Brian W. Pogue "Near-infrared optical tomography: endoscopic imaging approach", Proc. SPIE 6431, Multimodal Biomedical Imaging II, 643103 (20 February 2007); https://doi.org/10.1117/12.695217

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