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We present a novel way of optical detection of malignant cancer cell colonies by using multi-wavelength two-photon
excited fluorescence from an environmentally sensitive Styryl-9M dye. We show that the two-photon excited
fluorescence from colonies embedded in a tissue phantom depends on the type of cells as well as on the composition of
the phantoms. We use the ratio between the fluorescence intensities excited at 1100 and 1200 nm to distinguish between
samples containing no cell colonies, samples with colonies of normal cells and samples with cancer cells. The proposed
method is a promising tool for non-invasive deep tissue photodetection diagnostics and for precise localization of
malignant cells.
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Nikolay S. Makarov, Jean Starkey, Mikhail Drobizhev, Aleksander Rebane, "Hyperspectral two-photon near-infrared cancer imaging at depth," Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738048 (13 July 2009); https://doi.org/10.1117/12.822903