A portable and compact near-infrared spectral tomography system for predicting breast tumor response to neoadjuvant chemotherapy

Yan Zhao; Fadi El-Ghussein; Ziqi Zhang; Brian W. Pogue; Keith D. Paulsen; Shudong Jiang

doi:10.1117/12.2079210

5 March 2015 A portable and compact near-infrared spectral tomography system for predicting breast tumor response to neoadjuvant chemotherapy

Yan Zhao, Fadi El-Ghussein, Ziqi Zhang, Brian W. Pogue, Keith D. Paulsen, Shudong Jiang

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93190B (2015) https://doi.org/10.1117/12.2079210
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

A portable hybrid frequency domain (FD)-continuous wave (CW) Near-Infrared spectroscopy NIRS system has been developed for quantifying changes in total hemoglobin, oxygen saturation and water content in the breast during neoadjuvant chemotherapy. Simultaneous acquisition of two sets of 3 FD channels and 3 CW channels could be completed within 1 min. System calibration and homogeneous phantom measurement show phase variation less than 3% when PMT gain from 0.7 to 1.1 was used. The study of integrating this system into the workflow of clinical oncology practice is ongoing.

Citation Download Citation

Yan Zhao, Fadi El-Ghussein, Ziqi Zhang, Brian W. Pogue, Keith D. Paulsen, and Shudong Jiang "A portable and compact near-infrared spectral tomography system for predicting breast tumor response to neoadjuvant chemotherapy", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93190B (5 March 2015); https://doi.org/10.1117/12.2079210

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