Stamping SERS for creatinine sensing

Ming Li; Yong Du; Fusheng Zhao; Jianbo Zeng; Greggy M. Santos; Chandra Mohan; Wei-Chuan Shih

doi:10.1117/12.2078530

11 March 2015 Stamping SERS for creatinine sensing

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Greggy M. Santos, Chandra Mohan, Wei-Chuan Shih

Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 934004 (2015) https://doi.org/10.1117/12.2078530
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Urine can be obtained easily, readily and non-invasively. The analysis of urine can provide metabolic information of the body and the condition of renal function. Creatinine is one of the major components of human urine associated with muscle metabolism. Since the content of creatinine excreted into urine is relatively constant, it is used as an internal standard to normalize water variations. Moreover, the detection of creatinine concentration in urine is important for the renal clearance test, which can monitor the filtration function of kidney and health status. In more details, kidney failure can be imminent when the creatinine concentration in urine is high. A simple device and protocol for creatinine sensing in urine samples can be valuable for point-of-care applications. We reported quantitative analysis of creatinine in urine samples by using stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) based SERS substrate. S-SERS technique enables label-free and multiplexed molecular sensing under dry condition, while NPGD provides a robust, controllable, and high-sensitivity SERS substrate. The performance of S-SERS with NGPDs is evaluated by the detection and quantification of pure creatinine and creatinine in artificial urine within physiologically relevant concentration ranges.

Citation Download Citation

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Greggy M. Santos, Chandra Mohan, and Wei-Chuan Shih "Stamping SERS for creatinine sensing", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934004 (11 March 2015); https://doi.org/10.1117/12.2078530

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available