Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications

Adam K. Glaser; Rongxiao Zhang; Jacqueline Andreozzi; David Gladstone; Brian Pogue

doi:10.1117/12.2209126

1 March 2016 Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications

Adam K. Glaser, Rongxiao Zhang, Jacqueline Andreozzi, David Gladstone, Brian Pogue

Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 96940X (2016) https://doi.org/10.1117/12.2209126
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Cherenkov radiation has emerged as a novel source of light with a number of applications in the biomedical sciences. It’s unique properties, including its broadband emission spectrum, spectral weighting in the ultraviolet and blue wavebands, and local generation of light within a given tissue have made it an attractive source of light for techniques ranging from widefield imaging to oximetry and phototherapy. To help guide the future development of this field in the context of molecular imaging, quantitative estimates of the light fluence rates of Cherenkov radiation from a number of radionuclide and external radiotherapy beams in tissue was explored for the first time. Using Monte Carlo simulations, these values were found to be on the order of 0.1 – 1 nW/cm² per MBq/g for radionuclides and 1 – 10 μW/cm² per Gy/sec for external radiotherapy beams, dependent on the given waveband and optical properties. For phototherapy applications, the total light fluence was found to be on the order of nJ/cm² for radionuclides, and mJ/cm²for radiotherapy beams. To validate these findings, experimental validation was completed with an MV x-ray photon beam incident onto a tissue phantom, confirming the magnitudes of the simulation values. The results indicate that diagnostic potential is reasonable for Cherenkov excitation of molecular probes, but phototherapy may remain elusive at these relatively low fluence values.

Conference Presentation

Citation Download Citation

Adam K. Glaser, Rongxiao Zhang, Jacqueline Andreozzi, David Gladstone, and Brian Pogue "Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940X (1 March 2016); https://doi.org/10.1117/12.2209126

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