Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance

Ti Zhang; Huizhong Cui; Chia-Yi Fang; Long-Jyun Su; Shenqiang Ren; Huan-Cheng Chang; Xinmai Yang; M. Laird Forrest

doi:10.1117/1.JBO.18.2.026018

12 February 2013 Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance

Ti Zhang, Huizhong Cui, Chia-Yi Fang, Long-Jyun Su, Shenqiang Ren, Huan-Cheng Chang, Xinmai Yang, M. Laird Forrest

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 2, 026018 (February 2013). https://doi.org/10.1117/1.JBO.18.2.026018

Abstract

Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He⁺ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Ti Zhang, Huizhong Cui, Chia-Yi Fang, Long-Jyun Su, Shenqiang Ren, Huan-Cheng Chang, Xinmai Yang, and M. Laird Forrest "Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance," Journal of Biomedical Optics 18(2), 026018 (12 February 2013). https://doi.org/10.1117/1.JBO.18.2.026018

Published: 12 February 2013

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KEYWORDS

Tissues

Absorption

Photoacoustic spectroscopy

Tissue optics

Particles

Absorbance

Biomedical optics

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