Dr. Anand T. N. Kumar Profile

Dr. Anand T. N. Kumar

Associate Professor

SPIE Involvement:

Conference Program Committee | Author

Publications (25)

Proceedings Article | 12 April 2024 Open Access

Fluorescence lifetime-based tumor contrast enhancement using targeted near infrared probes (Conference Presentation) (Withdrawal Notice)

Rahul Pal, Anand Kumar

Proceedings Volume 11222, 112220G (2024) https://doi.org/10.1117/12.2545246

KEYWORDS: Tumors, Near infrared, Fluorescence, Surgery, Molecules

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Proceedings Article | 13 March 2024 Presentation

Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes

Anand T, Kumar, Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Hannah Collins, Corey Chan, Andrey Prilutskiy, MacLean Nasrallah, Tom Dijkhuis, Stefan Carp, Yin Hung, Peter Sadow, William Faquin, Brian Nahed, Allen Feng, Kevin Emerick, J. Sven Mieog, Alexander Vahrmeijer, Karthik Rajasekaran, John Y. Lee, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Kenneth Tanabe

Proceedings Volume PC12825, PC128250P (2024) https://doi.org/10.1117/12.3002108

KEYWORDS: Tumors, Tissues, Surgery, Near infrared, Fluorescence lifetime imaging, Fluorescence, Fluorescence intensity, Image-guided intervention, Contrast agents, Biological imaging

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SPIE Journal Paper | 13 May 2023 Open Access

Intraoperative molecular imaging: 3rd biennial clinical trials update

Patrick Bou-Samra, Najib Muhammad, Austin Chang, Ritesh Karsalia, Feredun Azari, Gregory Kennedy, Walter Stummer, Janos Tanyi, Linda Martin, Alexander Vahrmeijer, Barbara Smith, Eben Rosenthal, Patrick Wagner, David Rice, Amy Lee, Hafeez Abdelhafeez, Marcus M. Malek, Gary Kohanbash, Wilson Barry Edwards, Eric Henderson, Jane Skjøth-Rasmussen, Ryan Orosco, Summer Gibbs, Richard W. Farnam, Lalitha Shankar, Baran Sumer, Anand T. N. Kumar, Laura Marcu, Lei Li, Viktor Greuv, Edward J. Delikatny, John Y. K. Lee, Sunil Singhal

JBO, Vol. 28, Issue 05, 050901, (May 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.5.050901

KEYWORDS: Tumors, Surgery, Dyes, Clinical trials, Cancer, Resection, Fluorescence, Cancer detection, Near infrared, Tissues

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Proceedings Article | 28 March 2023 Open Access

First clinical results of fluorescence lifetime enhanced tumor imaging using exogenous agents (Conference Presentation) (Withdrawal Notice)

Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Stefan Carp, Corey Chan, Maclean Nasrallah, John Y. Lee, Yin Hung, Allen Feng, Kenneth Tanabe, Eben Rosenthal, Brian Nahed, Kevin Emerick, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Anand T. Kumar

Proceedings Volume PC12361, PC123610H (2023) https://doi.org/10.1117/12.2649241

KEYWORDS: Tumors, Fluorescence imaging, Fluorescence, Surgery, Molecules, Molecular photonics, Biomedical applications

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Proceedings Article | 17 March 2023 Presentation

In vivo imaging of CRISPRi-attenuated receptor expression by using a miniaturized near-infrared anti-EGFR probe (Conference Presentation)

Alexei Bogdanov, Suresh Gupta, Anand Kumar, Rahul Pal, Eric Schmidt

Proceedings Volume PC12398, PC123980E (2023) https://doi.org/10.1117/12.2648483

KEYWORDS: Tumors, In vivo imaging, Receptors, Cancer, Near infrared, Luminescence, Tumor growth modeling, Tissues, Optical imaging, Image registration

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Proceedings Article | 17 March 2023 Presentation

Fluorescence lifetime-enhanced tumor margin assessment in head and neck cancers using receptor targeted probes

Rahul Pal, Thinzar Lwin, Marisa Hom, Mark Varvares, Eben Rosenthal, Anand Kumar

Proceedings Volume 12354, 123540E (2023) https://doi.org/10.1117/12.2649378

KEYWORDS: Receptors, Tumors, Luminescence, Neck, Head, Cancer, Tissues, Surgery, Near infrared, Continuous wave operation

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Proceedings Article | 7 March 2023 Presentation

Modeling and optimization of system parameters for small animal fluorescence lifetime tomography

Murali K., Rahul Pal, Anand T.N. Kumar

Proceedings Volume PC12376, PC123760O (2023) https://doi.org/10.1117/12.2650768

KEYWORDS: Animal model studies, Tomography, Luminescence, Fluorescence tomography, Tissue optics, Optimization (mathematics), Cameras, 3D modeling, Signal to noise ratio, Microchannel plates

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Proceedings Article | 7 March 2023 Presentation

In-vivo fluorescence lifetime tomography for detection and quantification of immunotherapy marker, PD-L1

Rahul Pal, Aya Matsui, Murali K., Satoru Morita, Homan Kang, Hak Soo Choi, Dan Duda, Anand Kumar

Proceedings Volume PC12376, PC123760P (2023) https://doi.org/10.1117/12.2650664

KEYWORDS: Tumors, In vivo imaging, Tomography, Luminescence, Fluorescence tomography, Liver, Molecular imaging, Cancer, Biopsy

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Proceedings Article | 15 March 2021 Open Access

Tumor contrast enhancement using fluorescence lifetime: a new promise for image guided surgery (Conference Presentation) (Withdrawal Notice)

Anand Kumar, Rahul Pal, Lawrence Zukerberg, Kenneth Tanabe

Proceedings Volume 11625, 116250T (2021) https://doi.org/10.1117/12.2576446

KEYWORDS: Tumors, Luminescence, Surgery, Tissues, Image-guided intervention, Signal attenuation, Receptors, Near infrared, Multiplexing

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Proceedings Article | 5 March 2021 Presentation

Whole body fluorescence lifetime multiplexing of tumor receptor expression

Rahul Pal, Homan Kang, Hak Soo Choi, Gabriel Duda, Anand T. Kumar

Proceedings Volume 11624, 1162408 (2021) https://doi.org/10.1117/12.2578412

KEYWORDS: Tumors, Receptors, Luminescence, Multiplexing, In vivo imaging, Continuous wave operation, Tumor growth modeling, Tissues, Surveillance, Signal detection

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Proceedings Article | 5 March 2021 Presentation

Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng, Ailis Muldoon, Rahul Pal, Alana Ross, Pamela Pantazopoulos, Zdravka Medarova, Anand T. Kumar, Stefan Carp

Proceedings Volume 11634, 116340B (2021) https://doi.org/10.1117/12.2577699

KEYWORDS: Tumors, Breast, Near infrared spectroscopy, Breast cancer, Tumor growth modeling, Spectroscopy, Luminescence, Indocyanine green, Imaging spectroscopy, Fluorescence spectroscopy

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Proceedings Article | 5 March 2021 Poster + Presentation

Quantitative multiplexing in biological tissue using multispectral and fluorescence lifetime imaging

Rahul Pal, Anand T. Kumar

Proceedings Volume 11639, 116391V (2021) https://doi.org/10.1117/12.2578437

KEYWORDS: Multispectral imaging, Multiplexing, Tissues, Tissue optics, Luminescence, In vitro testing, Imaging systems, Visualization, Near infrared, Receptors

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Proceedings Article | 4 March 2019 Presentation

Fluorescence optical tomography using short-wave infrared light (Conference Presentation)

Steven Hou, Rahul Pal, Anand Kumar

Proceedings Volume 10874, 1087412 (2019) https://doi.org/10.1117/12.2510199

KEYWORDS: Short wave infrared radiation, Luminescence, Infrared radiation, Tomography, Optical tomography, Near infrared, Spatial resolution, Tissue optics, Tissues, Light scattering

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Proceedings Article | 1 March 2019 Open Access

Near-infrared oligonucleotide duplex sensors for imaging rapidly activated transcription factors in vitro and in situ

Alexei Bogdanov, Valeriy Metelev, Toloo Taghian, Ilya Solovyev, Anand T. Kumar, Surong Zhang, Alexander Savitsky

Proceedings Volume 10877, 1087702 (2019) https://doi.org/10.1117/12.2511124

KEYWORDS: Luminescence, Near infrared, Proteins, Molecules, In vivo imaging, Sensors, In vitro testing, Pancreas, Inflammation, Tissues

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Proceedings Article | 14 March 2018 Presentation

Fluorescence lifetime-based contrast enhancement of Indocyanine green-labelled tumors (Conference Presentation)

Anand Kumar, Stefan Carp

Proceedings Volume 10478, 104780A (2018) https://doi.org/10.1117/12.2290904

KEYWORDS: Tumors, Luminescence, Fluorescence spectroscopy, Surgery, Tissues, Indocyanine green, In vivo imaging, Breast, Brain, Target detection

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SPIE Journal Paper | 11 April 2017 Open Access

Fluorescence lifetime-based contrast enhancement of indocyanine green-labeled tumors

Anand Kumar, Stefan Carp, Jing Yang, Alana Ross, Zdravka Medarova, Chongzhao Ran

JBO, Vol. 22, Issue 04, 040501, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.040501

KEYWORDS: Tumors, Luminescence, Tissues, Atrial fibrillation, Breast, Solids, Fluorescence spectroscopy, Tissue optics, Error analysis

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SPIE Journal Paper | 8 April 2014 Open Access

Preclinical whole body time domain fluorescence lifetime multiplexing of fluorescent proteins

William Rice, Anand Kumar

JBO, Vol. 19, Issue 04, 046005, (April 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.4.046005

KEYWORDS: Continuous wave operation, Atrial fibrillation, Luminescence, Green fluorescent protein, Multiplexing, Skin, Tissues, In vivo imaging, Lymphatic system, In vitro testing

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SPIE Journal Paper | 20 April 2012 Open Access

In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium

Craig Goergen, Anand Kumar, Howard Chen, Alexei Bogdanov, David Sosnovik

JBO, Vol. 17, Issue 5, 056001, (April 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.5.056001

KEYWORDS: Luminescence, In vivo imaging, Liver, Heart, Fluorescence spectroscopy, Tissues, Signal detection, Biomedical optics, Continuous wave operation

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SPIE Journal Paper | 1 July 2010 Open Access

Lifetime-based tomographic multiplexing

Scott Raymond, David Boas, Brian Bacskai, Anand Kumar

JBO, Vol. 15, Issue 04, 046011, (July 2010) https://doi.org/10.1117/12.10.1117/1.3469797

KEYWORDS: Tomography, Multiplexing, Picosecond phenomena, In vivo imaging, Luminescence, Near infrared, Liver, Imaging systems, Sensors

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SPIE Journal Paper | 1 January 2008 Open Access

Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy

Phill Jones, Aneta Rozkalne, Melanie Meyer-Luehmann, Tara Spires-Jones, Alexandra Makarova, Anand Kumar, Oksana Berezovska, Brian Bacskai, Bradley Hyman

JBO, Vol. 13, Issue 01, 014008, (January 2008) https://doi.org/10.1117/12.10.1117/1.2837169

KEYWORDS: Atrial fibrillation, Fluorescence lifetime imaging, Fluorescence resonance energy transfer, Proteins, Image segmentation, Microscopy, Luminescence, Neurons, Picosecond phenomena, Brain

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Proceedings Article | 1 March 2007 Paper

A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis

Anand Kumar, Scott Raymond, David Boas, Brian Bacskai

Proceedings Volume 6434, 64340E (2007) https://doi.org/10.1117/12.699692

KEYWORDS: Luminescence, Tomography, Absorption, Fluorescence tomography, Sensors, Tissue optics, Signal to noise ratio, Diffusion, Biomedical optics

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Proceedings Article | 13 February 2007 Paper

Fluorescence tomography in a murine model of Alzheimer’s disease

Scott Raymond, Anand Kumar, Andrew Dunn, David Boas, Brian Bacskai

Proceedings Volume 6434, 64342H (2007) https://doi.org/10.1117/12.700199

KEYWORDS: Photons, Brain, Absorption, Luminescence, Monte Carlo methods, Reflection, Alzheimer's disease, Quantum efficiency, Image segmentation, Head

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SPIE Journal Paper | 1 September 2006 Open Access

Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays

Phill Jones, Lauren Herl, Oksana Berezovska, Anand Kumar, Brian Bacskai, Bradley Hyman

JBO, Vol. 11, Issue 05, 054024, (September 2006) https://doi.org/10.1117/12.10.1117/1.2363367

KEYWORDS: Proteins, Fluorescence resonance energy transfer, Fluorescence lifetime imaging, Luminescence, Picosecond phenomena, Alzheimer's disease, Data modeling, Molecules, Signal attenuation, Drug discovery

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Proceedings Article | 22 November 2005 Paper

Time resolved fluorescence imaging in diffuse media

Anand T. Kumar, Jesse Skoch, Frank Hammond III, Andrew Dunn, David Boas, Brian Bacskai

Proceedings Volume 6009, 60090Y (2005) https://doi.org/10.1117/12.630990

KEYWORDS: Luminescence, Sensors, Modulation, Tissues, Absorption, Reconstruction algorithms, Diffusion, Imaging systems, Tomography, Biological research

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Proceedings Article | 24 April 1998 Paper

Femtosecond spectroscopy of heme proteins

Paul Champion, Florin Rosca, Weizhi Wang, Anand Kumar, James Christian, Andrey Demidov

Proceedings Volume 3273, (1998) https://doi.org/10.1117/12.306112

KEYWORDS: Fluorescence correlation spectroscopy, Raman spectroscopy, Proteins, Iron, Photolysis, Femtosecond phenomena, Spectroscopy, Raman scattering, Chemical species, Chromophores

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