Dr. Bernhard H. Weigl Profile

Dr. Bernhard H. Weigl

Director at Global Health Labs Inc

SPIE Involvement:

Author

Publications (24)

Proceedings Article | 13 March 2013 Paper

Rapid screening test for gestational diabetes: public health need, market requirement, initial product design, and experimental results

Bernhard Weigl, Greg Zwisler, Roger Peck, Elizabeth Abu-Haydar

Proceedings Volume 8615, 86150L (2013) https://doi.org/10.1117/12.2008326

KEYWORDS: Gold, Glucose, Visualization, Blood, Capillaries, Manufacturing, Diagnostics, Diagnostic tests, Standards development, Plasma

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Proceedings Article | 9 March 2013 Paper

Instrument-free exothermic heating with phase change temperature control for paper microfluidic devices

Jered Singleton, Chris Zentner, Josh Buser, Paul Yager, Paul LaBarre, Bernhard Weigl

Proceedings Volume 8615, 86150R (2013) https://doi.org/10.1117/12.2005928

KEYWORDS: Oxides, Microfluidics, Magnesium, Manufacturing, Diagnostics, Control systems, Chemical reactions, Sodium, Prototyping, Temperature metrology

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Proceedings Article | 16 May 2011 Paper

Instrument-free nucleic acid amplification assays for global health settings

Paul LaBarre, David Boyle, Kenneth Hawkins, Bernhard Weigl

Proceedings Volume 8029, 802902 (2011) https://doi.org/10.1117/12.882868

KEYWORDS: Point-of-care devices, Blood, Luminescence, Chemistry, Lamps, Diagnostics, Microbiology, Diagnostic tests, Prototyping, Lawrencium

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Proceedings Article | 18 February 2010 Paper

Microfluidic diagnostics for low-resource settings

Kenneth Hawkins, Bernhard Weigl

Proceedings Volume 7593, 75930L (2010) https://doi.org/10.1117/12.845500

KEYWORDS: Microfluidics, Statistical analysis, Manufacturing, Lamps, Diagnostics, Raw materials, Diagnostic tests, System integration, Prototyping, Lawrencium

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Proceedings Article | 12 February 2008 Paper

Noninstrumented nucleic acid amplification assay

Bernhard Weigl, Gonzalo Domingo, Jay Gerlach, Dennis Tang, Darrel Harvey, Nick Talwar, Alex Fichtenholz, Bill van Lew, Paul LaBarre

Proceedings Volume 6886, 688604 (2008) https://doi.org/10.1117/12.763650

KEYWORDS: Medicine, Visualization, Blood, Crystals, Lamps, Diagnostics, Pathogens, Genetics, Sodium, Temperature metrology

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Proceedings Article | 23 January 2006 Paper

Fully integrated multiplexed lab-on-a-card assay for enteric pathogens

B. Weigl, J. Gerdes, P. Tarr, P. Yager, L. Dillman, R. Peck, S. Ramachandran, M. Lemba, M. Kokoris, M. Nabavi, F. Battrell, D. Hoekstra, E. Klein, D. Denno

Proceedings Volume 6112, 611202 (2006) https://doi.org/10.1117/12.644714

KEYWORDS: Microfluidics, Proteins, Point-of-care devices, Organisms, Magnetism, Diagnostics, Multiplexing, Pathogens, Diagnostic tests, Bacteria

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Proceedings Article | 23 December 2003 Paper

Modeling of microscale processes as a tool to speed development and enhance performance of microanalytical products

Bernhard Weigl, Ron Bardell

Proceedings Volume 5345, (2003) https://doi.org/10.1117/12.538592

KEYWORDS: Mathematical modeling, Microfluidics, Sensors, Blood, Polymers, Diffusion, Chemical analysis, Performance modeling, Process modeling, Instrument modeling

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Proceedings Article | 21 June 2002 Paper

Standard and high-throughput microfluidic disposables based on laminar fluid diffusion interfaces

Bernhard Weigl, Chris Morris, Natasa Kesler, Fred Battrell, Ron Bardell

Proceedings Volume 4626, (2002) https://doi.org/10.1117/12.472108

KEYWORDS: Microfluidics, Statistical analysis, Sensors, Blood, Particles, Molecules, Interfaces, Diffusion, Lab on a chip, Chemical analysis

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Proceedings Article | 21 May 2001 Paper

Microfluidic disposables for cellular and chemical detection: CFD model results and fluidic verification experiments

Ron Bardell, Bernhard Weigl, Natasa Kesler, Thomas Schulte, Jon Hayenga, Fred Battrell

Proceedings Volume 4265, (2001) https://doi.org/10.1117/12.427961

KEYWORDS: Microfluidics, Hematology, Visualization, Blood, Particles, Diffusion, Chemical detection, Absorbance, Chemical analysis, Biological research

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Proceedings Article | 15 March 2000 Paper

Novel immunoassay formats for integrated microfluidic circuits: diffusion immunoassays (DIA)

Bernhard Weigl, Anson Hatch, Andrew Kamholz, Paul Yager

Proceedings Volume 3912, (2000) https://doi.org/10.1117/12.379580

KEYWORDS: Microfluidics, Statistical analysis, Blood, Particles, Luminescence, Molecules, Diffusion, Lab on a chip, Chemical analysis, Signal detection

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Novel designs of integrated fluidic microchips allow separations, chemical reactions, and calibration-free analytical measurements to be performed directly in very small quantities of complex samples such as whole blood and contaminated environmental samples. This technology lends itself to applications such as clinical diagnostics, including tumor marker screening, and environmental sensing in remote locations. Lab-on-a-Chip based systems offer many *advantages over traditional analytical devices: They consume extremely low volumes of both samples and reagents. Each chip is inexpensive and small. The sampling-to-result time is extremely short. They perform all analytical functions, including sampling, sample pretreatment, separation, dilution, and mixing steps, chemical reactions, and detection in an integrated microfluidic circuit. Lab-on-a-Chip systems enable the design of small, portable, rugged, low-cost, easy to use, yet extremely versatile and capable diagnostic instruments. In addition, fluids flowing in microchannels exhibit unique characteristics ('microfluidics'), which allow the design of analytical devices and assay formats that would not function on a macroscale. Existing Lab-on-a-chip technologies work very well for highly predictable and homogeneous samples common in genetic testing and drug discovery processes. One of the biggest challenges for current Labs-on-a-chip, however, is to perform analysis in the presence of the complexity and heterogeneity of actual samples such as whole blood or contaminated environmental samples. Micronics has developed a variety of Lab-on-a-Chip assays that can overcome those shortcomings. We will now present various types of novel Lab- on-a-Chip-based immunoassays, including the so-called Diffusion Immunoassays (DIA) that are based on the competitive laminar diffusion of analyte molecules and tracer molecules into a region of the chip containing antibodies that target the analyte molecules. Advantages of this technique are a reduction in reagents, higher sensitivity, minimal preparation of complex samples such as blood, real-time calibration, and extremely rapid analysis.

Proceedings Article | 19 August 1999 Paper

Microfluidic approaches to immunoassays

Anson Hatch, Bernhard Weigl, Diane Zebert, Paul Yager

Proceedings Volume 3877, (1999) https://doi.org/10.1117/12.359334

KEYWORDS: Microfluidics, Statistical analysis, Sensors, Blood, Particles, Luminescence, Molecules, Diffusion, Light scattering, Signal detection

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Proceedings Article | 3 June 1999 Paper

Optical and electrochemical diffusion-based detection of analytes in complex samples using microfabricated flow structures (T-Sensors)

Bernhard Weigl, Robert Darling, Paul Yager, Jennah Kriebel, Kelly Mayes

Proceedings Volume 3606, (1999) https://doi.org/10.1117/12.350048

KEYWORDS: Microfluidics, Statistical analysis, Sensors, Electrodes, Ions, Silicon, Diffusion, Chemical analysis, Microfabrication, Lead

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Proceedings Article | 21 April 1999 Paper

Implementation of novel optical detection methods for clinically important blood analytes using microfabricated flow structures (T-Sensors)

Eric Altendorf, Bernhard Weigl

Proceedings Volume 3603, (1999) https://doi.org/10.1117/12.346743

KEYWORDS: Optical filters, Light sources, Statistical analysis, Sensors, Luminescence, Diffusion, Linear filtering, Image filtering, Shape analysis, Bandpass filters

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Proceedings Article | 10 September 1998 Paper

Design of microfluidic sample preconditioning systems for detection of biological agents in environmental samples

Paul Yager, Martin Afromowitz, Darrel Bell, Fred Forster, James Brody, Dong Qin, Catherine Cabrera, Mark Holl, Andrew Kamholz, Bernhard Weigl

Proceedings Volume 3515, (1998) https://doi.org/10.1117/12.322091

KEYWORDS: Microfluidics, Statistical analysis, Electrodes, Particles, Molecules, Chemical analysis, Biological research, Biological detection systems, Environmental sensing, Bacteria

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Proceedings Article | 1 May 1998 Paper

Development of flow-cytometry-based miniature chemical fluid analysis system using fluorescent microbeads

Ming-Chieh Huang, Martin Afromowitz, Ger van den Engh, Bernhard Weigl, Paul Yager

Proceedings Volume 3256, (1998) https://doi.org/10.1117/12.307061

KEYWORDS: Microfluidics, Scattering, Luminescence, Photomultipliers, Silicon, Argon ion lasers, Chemical analysis, Microfabrication, Semiconducting wafers, Signal detection

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Proceedings Article | 7 May 1997 Paper

Fluorescence and absorbance analyte sensing in whole blood and plasma based on diffusion separation in silicon-microfabricated flow structures

Bernhard Weigl, Greg Hixson, Margaret Kenny, Diane Zebert, Silver Dwinnell, Todd Buj, Paul Yager

Proceedings Volume 2980, (1997) https://doi.org/10.1117/12.273526

KEYWORDS: Microfluidics, Blood, Particles, Luminescence, Molecules, Ions, Silicon, Diffusion, Calcium, Semiconducting wafers

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Proceedings Article | 10 May 1996 Paper

Optical flow cytometry utilizing microfabricated silicon flow channels

Eric Altendorf, Elizabeth Iverson, David Schutte, Bernhard Weigl, Thor Osborn, Roya Sabeti, Paul Yager

Proceedings Volume 2678, (1996) https://doi.org/10.1117/12.239515

KEYWORDS: Microfluidics, Sensors, Blood, Silicon, Light scattering, Semiconductor lasers, Ray tracing, Optical flow, Microfabrication, Laser beam diagnostics

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Proceedings Article | 29 September 1995 Paper

Latest developments in gas sensing using correlation spectroscopy

John Dakin, Henry Edwards, Bernhard Weigl

Proceedings Volume 2508, (1995) https://doi.org/10.1117/12.221720

KEYWORDS: Light sources, Modulation, Interferometers, Sensors, Spectroscopy, Gases, Monochromators, Signal detection, Michelson interferometers, Absorption

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Proceedings Article | 29 September 1995 Paper

Optical sensor instrumentation using absorption- and fluorescence-based capillary waveguide optrodes

Bernhard Weigl, Sonja Draxler, Dietmar Kieslinger, H. Lehmann, Wolfgang Trettnak, Otto Wolfbeis, Max Lippitsch

Proceedings Volume 2508, (1995) https://doi.org/10.1117/12.221733

KEYWORDS: Optical fibers, Light emitting diodes, Waveguides, Sensors, Polymers, Capillaries, Glasses, Luminescence, Coating, Photodiodes

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Proceedings Article | 21 October 1994 Paper

Single-layer capillary optrode for carbon dioxide with adjustable sensitivity

Bernhard Weigl, Otto Wolfbeis

Proceedings Volume 2293, (1994) https://doi.org/10.1117/12.190960

KEYWORDS: Optical fibers, Gas sensors, Carbon dioxide, Sensors, Polymers, Capillaries, Ions, Silicon, Gases, Silicon carbide

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Proceedings Article | 21 October 1994 Paper

Capillary sensors: a design concept for optrodes

Bernhard Weigl, Otto Wolfbeis

Proceedings Volume 2293, (1994) https://doi.org/10.1117/12.190976

KEYWORDS: Waveguides, Sensors, Blood, Capillaries, Glasses, Silicon, Chemistry, Optical coatings, Fiber optics sensors, Absorption

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Proceedings Article | 10 March 1994 Paper

Robust carbon dioxide optrode based on a covalently immobilized pH indicator

Bernhard Weigl, Andrej Holobar, Nena Rodriguez, Otto Wolfbeis

Proceedings Volume 2068, (1994) https://doi.org/10.1117/12.170657

KEYWORDS: Optical fibers, Carbon dioxide, Sensors, Calibration, Polymers, Ions, Silicon, Coating, Manufacturing, Reflectivity

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Proceedings Article | 30 April 1993 Paper

Optical triple sensor for measuring pH, oxygen, and carbon dioxide in bioreactors

Bernhard Weigl, Andrej Holobar, Wolfgang Trettnak, Ingo Klimant, H. Kraus, Paul O'Leary, Otto Wolfbeis

Proceedings Volume 1796, (1993) https://doi.org/10.1117/12.143538

KEYWORDS: Light emitting diodes, Carbon dioxide, Sensors, Calibration, Electrodes, Polymers, Luminescence, Oxygen, Optoelectronics, Absorption

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Proceedings Article | 1 March 1992 Paper

Simple and versatile flow injection system for testing the performance of optical chemical sensors

Bernhard Weigl

Proceedings Volume 1587, (1992) https://doi.org/10.1117/12.56555

KEYWORDS: Potassium, Sensors, Luminescence, Ions, Fiber optics sensors, Sensor performance, Analog electronics, Monochromators, Environmental sensing, Chemical fiber sensors

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Showing 5 of 24 publications

Proceedings Volume Editor (1)

SPIE Conference Volume | 9 May 2011

Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII

Conference Committee Involvement (20)

Microfluidics, BioMEMS, and Medical Microsystems XXI

29 January 2023 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XX

22 January 2022 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XIX

6 March 2021 | Online Only, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XVIII

1 February 2020 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XVII

2 February 2019 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XVI

27 January 2018 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XV

28 January 2017 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XIV

13 February 2016 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XIII

7 February 2015 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XII

2 February 2014 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems XI

3 February 2013 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems X

23 January 2012 | San Francisco, California, United States

Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring

25 April 2011 | Orlando, Florida, United States

Microfluidics, BioMEMS, and Medical Microsystems IX

23 January 2011 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems VIII

25 January 2010 | San Francisco, California, United States

Microfluidics, BioMEMS, and Medical Microsystems VII

26 January 2009 | San Jose, California, United States

Microfluidics, BioMEMS, and Medical Microsystems VI

22 January 2008 | San Jose, California, United States

Microfluidics, BioMEMS, and Medical Microsystems V

22 January 2007 | San Jose, California, United States

Microfluidics, BioMEMS, and Medical Microsystems IV

23 January 2006 | San Jose, California, United States

Microfluidics, BioMEMS and Medical Microsystems III

25 January 2005 | San Jose, California, United States

Showing 5 of 20 Conference Committees

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