The complementary tools of atomic force microscopy (AFM) and Raman spectroscopy are used to extract information
on the microstructural properties of nanocomposite n-doped Si (n-Si) and Ag/n-Si films deposited on Si(111) substrates
at 400 °C and 550 °C. AFM measurements indicated that Ag/n-Si films had grain sizes and roughness values one order
of magnitude higher than n-doped Si films. The onset of metal-mediated crystallization of a-Si in Ag/n-Si films at ~ 400
°C is confirmed by Raman spectroscopy. Spectral Raman red-shifts of the transverse optical phonon region compared to
monocrystalline silicon originate from the interplay of phonon confinement and higher defect density caused by n-type
doping. Two protocols using the etchants ammonium fluoride - HF (2%::4% ) and ammonium citrate- acetic acid-hydrogen
peroxide (2.5%::2.5%::2%) solutions were investigated. A comparison between non-etched and etched films
showed little variability in roughness indicating retention of the microstructure.
Y2O3 nanocrystals doped with rare-earth ions have attracted considerable interest because of their chemical and thermal stability and their possible application in the light emitting devices and three-dimensional displays. Trivalent-rare-earth
ion-doped Y2O3 nanoparticles have been synthesized, and their spectroscopic studies have been carried out using visible laser excitation. The size of the nanoparticles has been estimated using atomic force microscope and scanning electron
microscope.
Oleic acid (OA)-Pluronic-coated iron oxide nanoparticles were synthesized and characterized by Fourier Transform
Infrared Spectroscopy (FT-IR) and Atomic Force Microscopy (AFM). FT-IR confirmed the bonding of oleic acid and
Pluronic (surfactant) to the nanoparticles. AFM measurements on these nanoparticles indicated a root mean square
(RMS) roughness, a measure of nanoparticle size of (50 ± 20) nm. The efficiency of these functionalized nanoparticles
was investigated by loading with 5-Fluorouracil (5-FU) in aqueous solution. AFM measurements were used to
characterize modified iron oxide nanoparticles and pancreatic MIA PaCa-2 cells, including size distribution, stability and
cellular uptake. Nanoparticles were added to MIA PaCa-2 cells and assayed for their cytotoxic effects after 24 and 48
hours. The outcome of this study demonstrated the effectiveness of oleic acid (OA)-Pluronic-coated iron oxide
nanoparticles as a non-toxic drug delivery agent for pancreatic cancer.
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