Photons are captured by rhodopsin in rod outer segments, where they are converted into an electrical signal. Modeling the light-sensitive electrical behavior of rods can reveal their biophysical mechanisms. However, most rod cell models are empirically based and lack biophysical meanings. In this paper, a model for rod cells based on the protein cascade transduction process and ion channels is presented. Based on the biochemical cascade of phototransduction in the rod outer segment, the model describes the formation of photocurrent and simulates the photocurrent response to different light stimuli. In addition, the model analyses the contribution of ion channels to light-response processes in photoreceptors and determines the relationship between light intensity and photovoltage response amplitude. This study presents an effective strategy for probing the internal phototransduction mechanism of rod cells. Furthermore, the model also provides an objective and quantitative description method for monitoring retinal diseases.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.