Mr. Chulho Daryl Hyun Profile

Chulho Daryl Hyun

Research Engineer at Wellman Ctr for Photomedicine

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Publications (12)

Proceedings Article | 7 March 2022 Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 14 March 2018 Presentation

Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging (Conference Presentation)

Biwei Yin, Zhonglie Piao, Chulho Daryl Hyun, Kensuke Nishimiya, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10471, 104710B (2018) https://doi.org/10.1117/12.2288747

KEYWORDS: Optical coherence tomography, In vivo imaging, Arteries, Gaussian beams, Cardiovascular magnetic resonance imaging, Wavefronts, Endoscopy, Fiber optics, Visualization, Image resolution

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Proceedings Article | 20 April 2017 Paper

Towards a clinical implementation of uOCT instrument for in vivo imaging of human airways

Hui Min Leung, Dongyao Cui, Timothy Ford, Daryl Hyun, Jing Dong, Biwei Yin, Susan Birket, George Solomon, Linbo Liu, Steven Rowe, Guillermo Tearney

Proceedings Volume 10056, 1005614 (2017) https://doi.org/10.1117/12.2253423

KEYWORDS: Liquids, Pathogens, Human subjects, Imaging systems, Optical coherence tomography, Coherence (optics), Tomography, In vivo imaging, Cystic fibrosis, Image resolution

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Proceedings Article | 19 April 2017 Presentation

Imaging demonstration of a flexible micro-OCT endobronchial probe (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Timothy Ford, Daryl Chulho Hyun, Hui Min Leung, Biwei Yin, Susan Birket, George Solomon, Steven Rowe, Guillermo Tearney

Proceedings Volume 10041, 1004109 (2017) https://doi.org/10.1117/12.2251449

KEYWORDS: Imaging systems, Photomedicine, Optical coherence tomography, Cystic fibrosis, Chronic obstructive pulmonary disease, In vivo imaging, Visualization, Motion models, Performance modeling, Imaging devices

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Proceedings Article | 27 April 2016 Presentation

Flexible micro-OCT endobronchial probe for imaging of mucociliary transport (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Carolin Unglert, Tim Ford, Robert Carruth, Daryl Hyun, Kanwarpal Singh, Susan Birket, George Solomon, Steve Rowe, Guillermo Tearney

Proceedings Volume 9691, 969107 (2016) https://doi.org/10.1117/12.2213057

KEYWORDS: Visualization, Cystic fibrosis, Chronic obstructive pulmonary disease, Pathogens, In vivo imaging, Photomedicine, Imaging systems, Particles, Lung, Liquids

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Mucociliary clearance (MCC) plays a significant role in maintaining the health of human respiratory system by eliminating foreign particles trapped within mucus. Failure of this mechanism in diseases such as cystic fibrosis and chronic obstructive pulmonary disease (COPD) leads to airway blockage and lung infection, causing morbidity and mortality. The volume of airway mucus and the periciliary liquid encapsulating the cilia, in addition to ciliary beat frequency and velocity of mucociliary transport, are vital parameters of airway health. However, the diagnosis of disease pathogenesis and advances of novel therapeutics are hindered by the lack of tools for visualization of ciliary function in vivo. Our laboratory has previously developed a 1-µm resolution optical coherence tomography method, termed Micro-OCT, which is capable of visualizing mucociliary transport and quantitatively capturing epithelial functional metrics. We have also miniaturized Micro-OCT optics in a first-generation rigid 4mm Micro-OCT endoscope utilizing a common-path design and an apodizing prism configuration to produce an annular profile sample beam, and reported the first in vivo visualization of mucociliary transport in swine. We now demonstrate a flexible 2.5 mm Micro-OCT probe that can be inserted through the instrument channel of standard flexible bronchoscopes, allowing bronchoscopic navigation to smaller airways and greatly improving clinical utility. Longitudinal scanning over a field of view of more than 400 µm at a frame rate of 40 Hz was accomplished with a driveshaft transduced by a piezo-electric stack motor. We present characterization and imaging results from the flexible micro-OCT probe and progress towards clinical translation. The ability of the bronchoscope-compatible micro-OCT probe to image mucus clearance and epithelial function will enable studies of cystic fibrosis pathogenesis in small airways, provide diagnosis of mucociliary clearance disorders, and allow individual responses to treatments to be monitored.

Proceedings Article | 27 April 2016 Presentation

Compensation of spectral artifacts in dual-modality intravascular optical coherence tomography and near-infrared spectroscopy (Conference Presentation)

Ali Fard, Joseph Gardecki, Giovanni Ughi, Chulho Hyun, Guillermo Tearney

Proceedings Volume 9689, 96892Z (2016) https://doi.org/10.1117/12.2219948

KEYWORDS: Near infrared spectroscopy, Optical coherence tomography, Light sources, Arteries, 3D image processing, In vivo imaging, Imaging technologies, Reliability, Data acquisition, Spectral calibration

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Intravascular optical coherence tomography (OCT) is a high-resolution catheter-based imaging method that provides three-dimensional microscopic images of coronary artery in vivo, facilitating coronary artery disease treatment decisions based on detailed morphology. Near-infrared spectroscopy (NIRS) has proven to be a powerful tool for identification of lipid-rich plaques inside the coronary walls. We have recently demonstrated a dual-modality intravascular imaging technology that integrates OCT and NIRS into one imaging catheter using a two-fiber arrangement and a custom-made dual-channel fiber rotary junction. It therefore enables simultaneous acquisition of microstructural and composition information at 100 frames/second for improved diagnosis of coronary lesions. The dual-modality OCT-NIRS system employs a single wavelength-swept light source for both OCT and NIRS modalities. It subsequently uses a high-speed photoreceiver to detect the NIRS spectrum in the time domain. Although use of one light source greatly simplifies the system configuration, such light source exhibits pulse-to-pulse wavelength and intensity variation due to mechanical scanning of the wavelength. This can be in particular problematic for NIRS modality and sacrifices the reliability of the acquired spectra. In order to address this challenge, here we developed a robust data acquisition and processing method that compensates for the spectral variations of the wavelength-swept light source. The proposed method extracts the properties of the light source, i.e., variation period and amplitude from a reference spectrum and subsequently calibrates the NIRS datasets. We have applied this method on datasets obtained from cadaver human coronary arteries using a polygon-scanning (1230-1350nm) OCT system, operating at 100,000 sweeps per second. The results suggest that our algorithm accurately and robustly compensates the spectral variations and visualizes the dual-modality OCT-NIRS images. These findings are therefore crucial for the practical application and clinical translation of dual-modality intravascular OCT-NIRS imaging when the same swept sources are used for both OCT and spectroscopy.

Proceedings Article | 8 March 2013 Paper

OCT imaging in chronic obstructive pulmonary disease

K. Ohtani, R. Lopez Lisbona, A. M. Lee, C. Hyun, T. Shaipanich, A. McWilliams, P. Lane, H. Coxson, C. MacAulay, S. Lam

Proceedings Volume 8565, 85652T (2013) https://doi.org/10.1117/12.2005206

KEYWORDS: Optical coherence tomography, Chronic obstructive pulmonary disease, Computed tomography, Lung, 3D image processing, Image segmentation, Americium, Cancer, In vivo imaging, Image resolution

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Proceedings Article | 8 March 2013 Paper

Correction of autofluorescence intensity for epithelial scattering by optical coherence tomography: a phantom study

H. Pahlevaninezhad, A. M. Lee, C. Hyun, S. Lam, C. MacAulay, P. Lane

Proceedings Volume 8565, 85652S (2013) https://doi.org/10.1117/12.2004531

KEYWORDS: Atrial fibrillation, Scattering, Optical coherence tomography, Signal attenuation, Light scattering, Tissues, Tissue optics, Imaging systems, Geometrical optics, Sensors

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SPIE Journal Paper | 1 July 2010 Open Access

Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina

Alireza Akhlagh Moayed, Sepideh Hariri, Chulho Hyun, Bruce Doran, Timothy Kraft, Shelley Boyd, Kostadinka Bizheva

JBO, Vol. 15, Issue 04, 040506, (July 2010) https://doi.org/10.1117/12.10.1117/1.3475489

KEYWORDS: Retina, Imaging systems, Optical coherence tomography, In vivo imaging, Reflectivity, Functional imaging, Eye, Cornea, 3D image processing, Image resolution

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Proceedings Article | 24 February 2009 Paper

The broadest spectral bandwidth suitable for in-vivo UHROCT imaging of human and animal retina at 1060nm

Sepideh Hariri, Alireza Moayed, Chulho Hyun, Vladimir Shidlovski, Aphrodite Dracopoulos, Shelley Boyd, Kostadinka Bizheva

Proceedings Volume 7168, 716807 (2009) https://doi.org/10.1117/12.809716

KEYWORDS: Retina, Absorption, Optical coherence tomography, Eye, Light sources, In vivo imaging, Eye models, Image resolution, Spectral resolution, Animal model studies

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Proceedings Article | 24 February 2009 Paper

High speed high resolution in vivo imaging of healthy rat retinas with FD-OCT operating at 1060nm

Sepideh Hariri, Aphrodite Dracopoulos, Alireza Akhlagh Moayed, Chulho Hyun, Zhao Ren, Prabakar Puvanathasan, Shelley Boyd, Kostadinka Bizheva

Proceedings Volume 7163, 716305 (2009) https://doi.org/10.1117/12.809768

KEYWORDS: Retina, Image resolution, Imaging systems, Eye, In vivo imaging, Optical coherence tomography, 3D image processing, 3D acquisition, Image visualization, Visualization

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Proceedings Article | 24 February 2009 Paper

Evaluation of hypoxic swelling of human cornea with high speed ultrahigh resolution optical coherence tomography

Kostadinka Bizheva, Chulho Hyun, Justin Eichel, Sepideh Hariri, Akshaya Mishra, David Clausi, Paul Fieguth, Trefford Simpson, Natalie Hutchings

Proceedings Volume 7163, 71631G (2009) https://doi.org/10.1117/12.809431

KEYWORDS: Cornea, Eye, Hypoxia, Optical coherence tomography, Image resolution, Tissues, Image segmentation, Imaging systems, Optical resolution, Visualization

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Showing 5 of 12 publications

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