We have developed VSHARP®, a suite of scatter correction solutions that have been incorporated into the commercially available cone-beam software development toolkit, CST (Varex Imaging, Salt Lake City, UT) enabling scatter correction to be applied as part of an entire CBCT reconstruction pipeline. The suite includes 2D VSHARP®, a deconvolution correction using asymmetric Gaussian kernels, 2D VSHARP-ML, a U-NET machine-learning correction, and 3D VSHARP®, a correction using a rapid finite-element Linear Boltzmann Transport Equation (LBTE) solver to estimate scatter in a manner similar to traditional stochastic Monte Carlo (MC) simulations. Of the three corrections, 3D VSHARP is the most accurate and flexible since it can be readily applied to arbitrary scanner geometries, protocols, and scan parts while the 2D VSHARP models may need to be regenerated for each configuration. On the other hand, 3D VSHARP is inherently slower since a minimum of two reconstruction passes are needed and the LBTE solver, while much faster than traditional MC, is still computationally intensive. The goal of this work was to minimize LBTE run times for (typically large) industrial datasets by optimizing parameter settings, particularly the choice of the sampling grid dimensions. This was achieved by applying a multi-objective genetic algorithm to find the Pareto front characterizing the tradeoff between speed and accuracy and identifying key operating points on the curve. Testing with 720 frames of 3720x3720 projection data to make a reconstruction volume of size 500x500x600, we found that excellent image quality can be obtained by using a coarse scatter grid size of 27x27x32 volume and 44x44 detector and a primary grid size of 246x246 x295 volume and 295x295 detector, both over 42 frames for a grand total of 21 seconds LBTE computation time. We show the Pareto characterization, as well as demonstrations of 3D VSHARP image quality with significantly reduced scatter-induced artifacts such as streaking and shading.
High quality cone-beam tomography (CBCT) reconstruction requires accurately estimating and subtracting the (often) large amount of scatter from the raw projection data. Although considerable attention has been paid to scatter correction algorithm development over the past several years, there still exists the need for a practical, general-purpose tool that is accurate, fast, and requires minimal calibration. Here, we introduce 3D VSHARP® which utilizes a finite element solver of the Linear Boltzmann Transport Equation (LBTE) to accurately and rapidly simulate photon transport through a model of the object being scanned and then scale and subtract the estimated scatter from raw projections. 3D VSHARP has been incorporated into the commercially available reconstruction software development toolkit, CST (Varex Imaging, Salt Lake City, UT) enabling scatter correction to be applied to arbitrary scanner configurations and geometries as part of an entire reconstruction pipeline. To set parameters for 3D VSHARP, the user chooses from a library of files that describe key physical aspects of the CT system, including its x-ray spectrum, detector response, and, if they exist, bowtie filter, and anti-scatter grid. The object model, which characterizes the spatial distribution of the atomic number and density of the scanned object, is automatically generated from the first-pass reconstruction which may, if desired, include CST’s existing kernel-based scatter correction 2D VSHARP®. We describe the new correction tool and show example reconstructions. High accuracy of scatter correction and excellent image quality were achieved with total reconstruction times on the order of 1 minute.
Complementary metal-oxide-semiconductors (CMOS) flat panel detectors (FPD) have steadily gained acceptance into medical imaging applications1-15. Selecting the proper detector technology for the imaging task requires optimization to balance the cost and the image quality. To facilitate this, fundamental detector performance of CMOS and a-Si panels were evaluated using the following quantitative imaging metrics: X-ray sensitivity, Noise Equivalent Dose (NED,) Noise Power Spectrum (NPS), Modulation Transfer Function (MTF), and Detective Quantum Efficiency (DQE). Imaging task measurements involved high-contrast and low-contrast resolution assessment. Varex FPDs evaluated for this study included: CMOS 3131 (150 μm pixel), a-Si 3030X (194 μm pixel), a-Si XRpad2 3025 (100 μm) and CMOS 2020 (100 μm pixel). Performance comparisons were organized by pixel size: large pixels, 150 μm CMOS and 194 μm a-Si, and small pixels, 100 μm in a-Si and CMOS technology. The results showed high dose DQE of the a-Si 3030X was about 10% higher than the CMOS 3131 between 0 - 1.8 cycles/mm, while beyond 1.8 cycles/mm, the CMOS performed better. The 3030X low dose DQE was higher than the 3131 between 0-1.3 cycles/mm, while the CMOS performance was higher beyond 1.3 cycles/mm. The high dose DQE of 100 μm a-Si was higher than the 100 μm CMOS for all frequencies. However, the low dose DQE of 100 μm CMOS was higher beyond 0.6 cycles/mm, while the 100 μm a-Si pixel had higher DQE only between 0 – 0.6 cycles/mm. Large pixel image quality (IQ) assessment favored a-Si pixel with 7% higher Contrast-to-Noise-Ratio (CNR) results for both high and low contrast-detail at 500 nGy. Small pixel CNR favored CMOS with ~38% better high contrast-detail and 12% greater low contrast-detail at ~500 nGy. Through these measurements that combine imaging metrics and image quality, we demonstrated a practical method for selecting the appropriate detector technology based on the requirements of the imaging applications.
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