Mr. Dvij Sharma Profile

Dvij Sharma

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Proceedings Article | 14 March 2023 Presentation + Paper

Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for PHOTOFRIN-mediated photodynamic therapy

Weibing Yang, Vivek Rastogi, Hongjing Sun, Dvij Sharma, Brian Wilson, Robert Hadfield, Timothy Zhu

Proceedings Volume 12359, 1235908 (2023) https://doi.org/10.1117/12.2652590

KEYWORDS: Oxygen, Dosimetry, Photodynamic therapy, Signal intensity, Spectroscopy, Indium gallium arsenide, Phosphorescence

Read Abstract +

Direct detection of singlet-state oxygen ([¹O₂]) constitutes the holy grail dosimetric method for type II PDT, a goal that can be quantified using multispectral singlet oxygen dosimetry (MSOLD). However, the short lifetime and extremely weak nature of the singlet oxygen signal produced has given rise to a need to improve MSOLD signal-to-noise ratio. This study examines methods for optimizing MSOLD signal acquisition, specifically employing an orthogonal arrangement between detection and PDT treatment light, consisting of two fiber optics - connected to a 632-nm laser and an InGaAs detector respectively. Light collected by the InGaAs detector is then passed through a filter wheel, where spectral emission measurements are taken at 1200 nm, 1240 nm, 1250 nm, 1270 nm, and 1300 nm. The data, after fitting to the fluorescence background and a gaussian-fit for the singlet oxygen peak, is established for the background-subtracted singlet oxygen emission signal. The MSOLD signal is then compared with the singlet oxygen explicit dosimetry (SOED) results, based on direct measurements of in-vivo light fluence (rate), in-vivo Photofrin concentration, and tissue oxygenation concentration. This study focuses on validating the sensitivity and minimum detectability of MSOLD signal in various in-vitro conditions. Finally, the MSOLD device will be tested in Photofrin-mediated PDT for mice bearing Radiation- Induced Fibrosarcoma (RIF) tumors.

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