Screening colonoscopy is used to detect and remove lesions prior to progressing to colorectal cancer, but some lesions go undetected due to poor visual contrast in white light endoscopy. We present a retrofit clinical colonoscope capable of multispectral, topographic, and blood flow imaging for improving lesion contrast. We develop a custom fiber bundle to enable simultaneous illumination with commercial and research light sources. The research light source consists of nine wavelengths (405nm-659nm) for multispectral imaging and a high-coherence source for speckle-flow imaging. Point sources circling the image sensor are individually toggled to generate topographic maps with photometric stereo.
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