The aim of this work is to draw the attention of the biophotonics community to a stochastic decomposition method (SDM) to potentially model 2-D scans of light scattering data from epithelium mucosa tissue. The emphasis in this work is on the proposed model and its theoretical pinning and foundation. Unlike previous works that analyze scattering signal at one spot as a function of wavelength or angle, our method statistically analyzes 2-D scans of light scattering data over an area. This allows for the extraction of texture parameters that correlate with changes in tissue morphology, and physical characteristics such as changes in absorption and scattering characteristics secondary to disease, information that could not be revealed otherwise. The method is tested on simulations, phantom data, and on a limited preliminary in-vitro animal experiment to track mucosal tissue inflammation over time, using the area Az under receiver operating characteristics (ROC) curve as a performance measure. Combination of all the features results in an Az value up to 1 for the simulated data, and Az>0.927 for the phantom data. For the tissue data, the best performances for differentiation between pairs of various levels of inflammation are 0.859, 0.983, and 0.999.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.