Dr. Glenn S. Edwards Profile

Dr. Glenn S. Edwards

Physics Professor at Duke Univ

SPIE Involvement:

Author

Publications (22)

Proceedings Article | 25 February 2008 Paper

Pressure (mechanical) effects in infrared tissue ablation

Glenn Edwards, Wolfgang Wagner, Adam Sokolow, Robert Pearlstein

Proceedings Volume 6854, 685410 (2008) https://doi.org/10.1117/12.776999

KEYWORDS: Tissues, Free electron lasers, Acoustics, Natural surfaces, Laser ablation, Brain, Infrared radiation, Fourier transforms, Interferometers, Laser applications

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Proceedings Article | 13 April 2005 Paper

Applications of free electron lasers to the biological and physical sciences

Glenn Edwards

Proceedings Volume 5725, (2005) https://doi.org/10.1117/12.598150

KEYWORDS: Free electron lasers, Infrared radiation, Electrons, Infrared spectroscopy, Spectroscopy, Gamma radiation, Molecules, Tissues, Ultraviolet radiation, Molecular spectroscopy

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Proceedings Article | 19 November 2003 Paper

Laser-induced alterations of the infrared light absorption by biological tissues: radiometric and spectroscopic measurements

Emil Sobol, Alexander Sviridov, Moshe Kitai, Victor Bagratashvili, Jonathan Gilligan, Glenn Edwards

Proceedings Volume 4829, (2003) https://doi.org/10.1117/12.530961

KEYWORDS: Absorption, Tissues, Cartilage, Spectroscopy, Free electron lasers, Cornea, Pulsed laser operation, Infrared spectroscopy, Infrared radiation, FT-IR spectroscopy

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Proceedings Article | 1 April 2002 Paper

Heat diffusion and chemical kinetics in Mark-III FEL tissue ablation

Glenn Edwards, M. Shane Hutson, Susanne Hauger

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461378

KEYWORDS: Free electron lasers, Proteins, Diffusion, Picosecond phenomena, Collagen, Laser ablation, Thermal modeling, Tissues, Laser tissue interaction, Explosives

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Proceedings Article | 1 April 2002 Paper

UV/time-resolved FTIR beamline at Duke FEL Laboratory

M. Shane Hutson, Richard Palmer, Angela Gillikin, Ming-Shien Chang, Vladimir Litvinenko, Glenn Edwards

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461383

KEYWORDS: FT-IR spectroscopy, Free electron lasers, Ultraviolet radiation, Mirrors, Spectroscopy, Synchrotron radiation, Light sources, Interferometers, Mid-IR, Infrared spectroscopy

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Proceedings Article | 1 April 2002 Paper

Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 um

Glenn Edwards, M. Shane Hutson, Susanne Hauger, John Kozub, Jin-Hui Shen, Charles Shieh, Katie Topadze, Karen Joos

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461379

KEYWORDS: Free electron lasers, Tissues, Proteins, Picosecond phenomena, Laser ablation, Cornea, Diffusion, Explosives, Collagen, Retina

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Proceedings Article | 28 April 2000 Paper

Light source capabilities and applications research at the Duke FEL Laboratory

Glenn Edwards, W. Fowler, M. Shane Hutson, Vladimir Litvinenko

Proceedings Volume 3925, (2000) https://doi.org/10.1117/12.384258

KEYWORDS: Cornea, Free electron lasers, Laser ablation, Sensors, Light sources, Wound healing, Laser vision correction, FT-IR spectroscopy, LASIK, Surgery

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Proceedings Article | 28 April 2000 Paper

Alterations of absorption coefficient of tissue water as a result of the heating under the IR-FEL radiation with different wavelengths

Emil Sobol, Alexander Sviridov, Moishe Kitai, Jonathan Gilligan, Glenn Edwards

Proceedings Volume 3925, (2000) https://doi.org/10.1117/12.384255

KEYWORDS: Absorption, Tissues, FT-IR spectroscopy, Cartilage, Cornea, Temperature metrology, Free electron lasers, Laser tissue interaction, Sensors, Spectroscopy

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Proceedings Article | 25 October 1999 Paper

Fourier transform infrared picosecond time-resolved spectroscopy with a UV free-electron laser pump synchrotron IR probe

Richard Palmer, Gregory Smith, Vladimir Litvinenko, Glenn Edwards

Proceedings Volume 3775, (1999) https://doi.org/10.1117/12.366638

KEYWORDS: FT-IR spectroscopy, Infrared spectroscopy, Free electron lasers, Picosecond phenomena, Synchrotrons, Infrared radiation, Spectroscopy, Synchrotron radiation, Time resolved spectroscopy, Ultraviolet radiation

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Proceedings Article | 14 June 1999 Paper

Effect of wavelength on threshold and kinetics of tissue denaturation under laser radiation

Emil Sobol, Alexander Sviridov, Moishe Kitai, Jonathan Gilligan, Norman Tolk, Glenn Edwards

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.349995

KEYWORDS: Absorption, Cartilage, Light scattering, Free electron lasers, Cornea, Laser damage threshold, Laser tissue interaction, Tissues, Laser scattering, Tissue optics

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We consider the denaturation process as an alteration in ordered organization of tissue structure and study the threshold and kinetics of laser-induced denaturation in cartilage and cornea undergoing irradiation from a free electron laser (FEL) in the wavelength range 2.2 - 8.5 (mu) . Light-scattering by cartilage samples was measured in real- time during FEL irradiation using a 630-nm diode laser and a diode array with time resolution of 10 ms. We found that denaturation threshold is slightly lower than that for cartilage, and both depend on laser wavelength. A strong inverse correlation between denaturation thresholds and the absorption spectrum of the tissue is observed. Only for the wavelength region near the 3 (mu) water absorption band was the denaturation threshold not inversely proportional to the absorption coefficient. We believe this was because the radiation penetration depth was very small in this high- absorption region, so tissue denaturation occurred only in a layer too thin to produce significant light scattering. ATR spectra of 2.4 mm thick cartilage samples was measured before and after irradiation at 6.0 and 2.2 (mu) . At 6.0 (mu) , where the absorption is high, the spectrum of the irradiated (front) surface showed changes, while the spectrum of the back surface was identical to that before irradiation. This difference results from dramatic denaturation (with chemical bond breaking) at the front surface due to laser heating in a small absorption depth. For 2.2 (mu) irradiation, where the absorption is small, the spectra of the front and back of the irradiated sample were unchanged from before irradiation, while light scattering alteration shown the denaturation process began, for laser fluences above the denaturation threshold. This indicates that the absorption is too small to produce deep denaturation of the tissue with dramatic alteration of structure. Thus, we have shown that light scattering is useful for measuring denaturation thresholds and kinetics for biotissues except where the initial absorptivity is very high.

Proceedings Article | 5 June 1998 Paper

Hollow-waveguide-delivered infrared free-electron laser for microsurgical applications

Jin-Hui Shen, Karen Joos, James Harrington, Denis O'Day, Glenn Edwards

Proceedings Volume 3262, (1998) https://doi.org/10.1117/12.309466

KEYWORDS: Free electron lasers, Hollow waveguides, Infrared radiation, Waveguides, Tissues, Infrared lasers, Surgery, Laser tissue interaction, Eye, Laser therapeutics

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Proceedings Article | 26 May 1997 Paper

Cultured human cornea healing process after free-electron-laser ablation

Jin-Hui Shen, Karen Joos, Debra Shetlar, Richard Robinson, Gurpreet Thind, Glenn Edwards, Denis O'Day

Proceedings Volume 2971, (1997) https://doi.org/10.1117/12.275106

KEYWORDS: Cornea, Free electron lasers, Laser ablation, Air contamination, Excimer lasers, Infrared radiation, Eye, Tissues, Photography, Infrared lasers

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Proceedings Article | 17 May 1996 Paper

Free Electron Laser (FEL) laser-tissue interaction with human cornea and optic nerve

Karen Joos, Glenn Edwards, Jin-Hui Shen, Debra Shetlar, Richard Robinson, Denis O'Day

Proceedings Volume 2673, (1996) https://doi.org/10.1117/12.240051

KEYWORDS: Free electron lasers, Tissues, Cornea, Optic nerve, Laser tissue interaction, Laser development, Infrared radiation, Tissue optics, Picosecond phenomena, Ophthalmology

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Proceedings Article | 23 April 1996 Paper

Midinfrared ablation of dentin with the Vanderbilt FEL

David Harris, Lou Reinisch, Glenn Edwards, Michael Yessik, Shahid Ashrafi, Joseph Santos-Sacchi

Proceedings Volume 2672, (1996) https://doi.org/10.1117/12.238765

KEYWORDS: Laser ablation, Free electron lasers, Scanning electron microscopy, Absorption, Teeth, Spectroscopy, Tissues, Natural surfaces, Laser dentistry, FT-IR spectroscopy

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SPIE Journal Paper | 1 May 1995

Biomedical and potential clinical applications for pulsed lasers operating near 6.45 μm

Glenn Edwards

OE, Vol. 34, Issue 05, (May 1995) https://doi.org/10.1117/12.10.1117/12.201620

KEYWORDS: Free electron lasers, Laser applications, Laser ablation, Biomedical optics, Pulsed laser operation, Optical parametric oscillators, Optics, Picosecond phenomena, Proteins, Tissues

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Proceedings Article | 17 August 1994 Paper

Partitioning-of-energy model for laser ablation of tissue

Glenn Edwards, Jerri Tribble, J. Johnson

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182929

KEYWORDS: Thermal modeling, Proteins, Laser ablation, Laser tissue interaction, Infrared radiation, Tissues, Absorption, Photons, Biopolymers, Explosives

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Proceedings Article | 27 July 1994 Paper

Two years of FEL applications research in biological physics

Glenn Edwards, Regan Logan, Michael Copeland, Lou Reinisch, Jeffrey Davidson, J. Johnson, Robert Maciunas, Marcus Mendenhall, Robert Ossoff, Jerri Tribble, Jay Werkhaven, Denis O'Day

Proceedings Volume 2138, (1994) https://doi.org/10.1117/12.181340

KEYWORDS: Free electron lasers, Physics, Energy transfer, Infrared radiation, Tissues, Spectroscopy, Biological research, Biopolymers, Sensors, Medicine

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Proceedings Article | 27 July 1994 Paper

Pulsed IR-FEL applications for the characterization of infrared optical materials

Richard Mu, Don Henderson, J. Johnson, Glenn Edwards

Proceedings Volume 2138, (1994) https://doi.org/10.1117/12.181347

KEYWORDS: Thermal effects, Laser beam diagnostics, Absorption, Refractive index, Infrared radiation, Free electron lasers, Sensors, Silica, Nonlinear optics, Thermal modeling

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Proceedings Article | 14 July 1993 Paper

FEL investigations of energy transfer in condensed phase systems

Don Henderson, Richard Mu, Enrique Silberman, J. Johnson, Glenn Edwards

Proceedings Volume 1854, (1993) https://doi.org/10.1117/12.148033

KEYWORDS: Free electron lasers, Silica, Picosecond phenomena, Thermal effects, Laser beam diagnostics, Energy transfer, Absorption, Absorbance, Molecules, Refractive index

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SPIE Journal Paper | 1 February 1993

Biomedical applications of free-electron lasers

Glenn Edwards, J. Johnson, John Kozub, Jerri Tribble, Katrina Wagner

OE, Vol. 32, Issue 02, (February 1993) https://doi.org/10.1117/12.10.1117/12.60753

KEYWORDS: Free electron lasers, Infrared radiation, Biopolymers, Spectroscopy, Biomedical optics, Absorption, Energy transfer, Laser applications, Visible radiation, FT-IR spectroscopy

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Proceedings Article | 7 August 1992 Paper

Applications of free-electron lasers to measurements of energy transfer in biopolymers and materials

Glenn Edwards, J. Johnson, John Kozub, Jerri Tribble, Katrina Wagner

Proceedings Volume 1646, (1992) https://doi.org/10.1117/12.137462

KEYWORDS: Free electron lasers, Biopolymers, Spectroscopy, Energy transfer, Infrared radiation, FT-IR spectroscopy, Visible radiation, Raman spectroscopy, Physics, Infrared detectors

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Proceedings Article | 1 December 1991 Paper

Vanderbilt Free-Electron Laser Center for Biomedical and Materials Research

Norman Tolk, Charles Brau, Glenn Edwards, Giorgio Margaritondo, Jim McKinley

Proceedings Volume 1552, (1991) https://doi.org/10.1117/12.50587

KEYWORDS: Free electron lasers, X-rays, Laser tissue interaction, Molecules, Biomedical optics, Medical research, Physics, Laser therapeutics, Semiconductors, Photons

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