Hans Jorgen Gundersen, Soren Hansen, Albert Gjedde, Hans Stodkilde-Jorgensen, Jorgen Marqversen, Ralf Agger, Tom Andersen, Charlotte Fleischer, Mikkel Petersen, Marianne Hokland, Egil Hulgaard, Jan Jorgensen, Ulrik Skands
KEYWORDS: Positron emission tomography, Magnetic resonance imaging, Scanners, Point spread functions, Visualization, Tissues, Image registration, Germanium, Medical imaging, Data conversion
A method for precise and sensitive organ specific quantification of 124I (124IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.
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