Mr. Jonathan I. Sperl Profile

Jonathan I. Sperl

at GE Research

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Author

Publications (3)

Proceedings Article | 25 February 2009 Paper

Quantitative analysis with the optoacoustic/ultrasound system OPUS

Christoph Haisch, Karin Zell, Jonathan Sperl, Mika Vogel, Reinhard Niessner

Proceedings Volume 7177, 717702 (2009) https://doi.org/10.1117/12.810739

KEYWORDS: Ultrasonography, Reconstruction algorithms, Quantitative analysis, Transducers, Scattering, Laser systems engineering, Pulsed laser operation, Absorption, Signal to noise ratio, Photoacoustic spectroscopy

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The OPUS (Optoacoustic plus Ultrasound) system is a combination of a medical ultrasound scanner with a highrepetition rate, wavelength-tunable laser system and a suitable triggering interface to synchronize the laser and the ultrasound system. The pulsed laser generates an optoacoustic (OA), or photoacoustic (PA), signal which is detected by the ultrasound system. Alternatively, imaging in conventional ultrasound mode can be performed. Both imaging modes can be superimposed. The laser light is coupled into the tissue laterally, parallel to the ultrasound transducer, which does not require for any major modification to the transducer or the ultrasound beam forming. This was a basic requirement on the instrument, as the intention of the project was to establish the optoacoustic imaging modality as add-on to a conventional standard ultrasound instrument. We believe that this approach may foster the introduction of OA imaging as routine tool in medical diagnosis. Another key aspect of the project was to exploit the capabilities of OA imaging for quantitative analysis. The intention of the presented work is to summarize all steps necessary to extract the significant information from the PA raw data, which are required for the quantification of local absorber distributions. We show results of spatially resolved absorption measurements in scattering samples and a comparison of four different image reconstruction algorithms, regarding their influence on lateral resolution as well as on the signal to noise ratio for different sample depths and absorption values. The reconstruction algorithms are based on Fourier transformation, on a generalized 2D Hough transformation, on circular back-projection and the classical delay-and-sum approach which is implemented in most ultrasound scanners. Furthermore, we discuss the influence of a newly developed laser source, combining diode and flash lamp pumping. Compared to all-flash-lamp pumped systems it features a significantly higher pulse-to-pulse stability, which is required for sensitive and precise quantitative analyses.

Proceedings Article | 17 July 2007 Paper

OPUS: optoacoustic imaging combined with conventional ultrasound for breast cancer detection

C. Haisch, K. Zell, J. Sperl, S. Ketzer, M. Vogel, P. Menzenbach, R. Niessner

Proceedings Volume 6631, 663105 (2007) https://doi.org/10.1117/12.727971

KEYWORDS: Ultrasonography, Transducers, Absorption, Tissue optics, Photoacoustic spectroscopy, Breast cancer, Imaging systems, Pulsed laser operation, Tissues, Blood

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Proceedings Article | 17 July 2007 Paper

Photoacoustic image reconstruction: a quantitative analysis

Jonathan Sperl, Karin Zell, Peter Menzenbach, Christoph Haisch, Stephan Ketzer, Markus Marquart, Hartmut Koenig, Mika Vogel

Proceedings Volume 6631, 663103 (2007) https://doi.org/10.1117/12.727839

KEYWORDS: Reconstruction algorithms, Signal to noise ratio, Superposition, Fourier transforms, Image restoration, Data acquisition, Tissue optics, Hough transforms, Ultrasonography, Transducers

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