Shifted position-diffuse reflectance imaging is a technique for the non-invasive assessment of microcirculation. In this study, its lateral resolution and imaging depth were determined to be 95 μm and 295 μm, respectively, by Monte-Carlo simulations.
In an incoherent optical fiber bundle (IOFB), the spatial correspondence of its both ends is not given, which usually complicates its handling. There are, however, medical applications for which IOFBs are well suited: Ultra-high spatial resolution fiber spectroscopy, for example, requires densely packed thin fibers on one side of the bundle, while on the other bundle side a flexible arrangement of the fibers is necessary to prevent overlapping of the individual spectra. To make such IOFBs usable for information transmission, a calibration routine to match input and output of the bundle is necessary. The aim of the present work is to establish a calibration routine for densely packed IOFBs with a single fiber core diameter of 23 μm. A HeNe laser focused to illuminate only one single fiber at a time is forming the basis of the experimental setup. An image of the output side is taken, the respective brightness peak is detected and its coordinates are stored in a look-up table (LUT) to allow the fiber bundle input to be reconstructed from its signal output. Several validation and calibration steps have been established to ensure a reliable fiber assignment. In a test run, 94.3% of the 1,374 fibers of the bundle used for proof of concept could be assigned exactly and used for image transmission.
Lasers have become a generally accepted tool for surgery due to their advantages compared to traditional approaches like the scalpel. However, lasers lack a feedback system for safe laser guidance. This problem prevents the potential laser application for a lot of medical cases in the clinical environment. In this work, a new tissue differentiation modality which might be implemented as a feedback system using remote speckle-sensing is presented. This modality is tested on three tissue types and the results are discussed.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.