The purpose is to determine whether diffuse reflectance spectroscopy (DRS) can provide optical guidance during deep brain stimulation (DBS) surgery. Experiments on monkey ex vivo brains have been performed to ensure DRS methods could differentiate white and gray matter. In this study, we use principal component analysis (PCA) to determine the composition of tissue in front of the stimulation electrode. Furthermore, our work tackles the mechanical consequences of implementing an optical probe in a DBS electrode. This multidisciplinary project shows that DRS can be used as a non-invasive, cost-effective and real-time tissue characterization.
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