Dr. Punit Prakash Profile

Dr. Punit Prakash

Associate Professor at Kansas State Univ

SPIE Involvement:

Author

Publications (17)

Proceedings Article | 29 March 2024 Presentation + Paper

Prediction model for local tumor progression following microwave ablation treatment of early-stage lung cancer

Pinyo Taeprasartsit, Jan Sebek, Punit Prakash, Robert Short, Henky Wibowo

Proceedings Volume 12928, 129281H (2024) https://doi.org/10.1117/12.3006299

KEYWORDS: Tumors, Ablation, Data modeling, Lung cancer, Computed tomography

Read Abstract +

Proceedings Article | 16 March 2020 Paper

A personalized approach for microwave ablation treatment planning fusing radiomics and bioheat transfer modeling

Pinyo Taeprasartsit, Chanok Pathompatai, Kasidit Jusomjai, Henky Wibowo, Jan Sebek, Punit Prakash

Proceedings Volume 11315, 1131532 (2020) https://doi.org/10.1117/12.2549790

KEYWORDS: Tumors, Microwave radiation, Tissues, Lung, 3D modeling, Data modeling, Neural networks

Read Abstract +

The use of percutaneous and bronchoscopic microwave ablation to treat both primary and secondary lung tumors has been growing recently. These ablation systems are typically accompanied by an ablation planning system to optimize the treatment outcome by ensuring adequate margin in the expected ablation zone during the planning phase. The planning system utilizes pre-operative CT scan to identify the tumor and recommend microwave probe position. Radiomics is a process of converting medical images into higher-dimensional data and subsequent mining of data to reveal underlying pathophysiology for enhancing clinical decision support making. Radiomics analysis have shown promises in capturing distinct tumor characteristics and predicting prognosis of the tumor. Here, we present a new method to predict microwave ablation zones by supplementing a bioheat transfer model of microwave tissue ablation with microwave sensitive radiomics features. We hypothesize that supplementing traditional bioheat transfer modeling with microwave sensitive radiomics features will generate a more accurate and personalized ablation prediction that will lead to better treatment outcome. Inputs to the bioheat transfer modeling approach include the geometry of the target tumor, physical characteristics of the tissue, and dimensions of the microwave ablation applicator. The radiomics algorithm extracts characteristics of the targeted tumor’s size and shape, as well as texture characteristics, from pre-operative CT images. We employed cascaded segmentation based on RetinaNet and U-Net to obtain a tumor’s size and shape. Then, a segmented tumor is employed for texture analysis through a set of regression convolutional neural networks. These tumor characteristics are employed as radiomics features for more accurate dose prediction and margin for microwave ablation treatment. We present the preliminary results of a study using images from clinical lung tumor cases to predict ablation treatment outcome, with patient-specific tissue biophysical properties based on radiomics features.

Proceedings Article | 8 March 2019 Paper

An enhanced hybrid MRI thermometry technique for monitoring microwave thermal therapy

A. Alivar, P. Faridi, P. Prakash, B. Natarajan

Proceedings Volume 10951, 109512P (2019) https://doi.org/10.1117/12.2511666

KEYWORDS: Image processing, Magnetic resonance imaging, Microwave radiation, Thermometry, Temperature metrology, Wavelets, Phase shifts, Tissues, Motion models, Error analysis

Read Abstract +

Proceedings Article | 22 February 2017 Paper

Flexible microwave ablation applicator for the treatment of pulmonary malignancies

Austin Pfannenstiel, Tom Keast, Steve Kramer, Henky Wibowo, Punit Prakash

Proceedings Volume 10066, 100660M (2017) https://doi.org/10.1117/12.2255504

KEYWORDS: Lung, Microwave radiation, Tissues, Antennas, Radiofrequency ablation, Blood circulation, Software development, Finite element methods, In vivo imaging, Tumors, Prototyping, Temperature metrology, Computed tomography

Read Abstract +

Proceedings Article | 22 February 2017 Paper

Global microwave endometrial ablation for menorrhagia treatment

Hojjatollah Fallahi, Jan Šebek, Eric Frattura, Jessica Schenck, Punit Prakash

Proceedings Volume 10066, 100660K (2017) https://doi.org/10.1117/12.2254097

KEYWORDS: Microwave radiation, Antennas, Uterus, Finite element methods, Liver, Laser ablation

Read Abstract +

Proceedings Article | 12 March 2015 Paper

Multiple-antenna microwave ablation: analysis of non-parallel antenna implants

Souvick Mukherjee, Sergio Curto, Nathan Albin, Bala Natarajan, Punit Prakash

Proceedings Volume 9326, 93260U (2015) https://doi.org/10.1117/12.2080349

KEYWORDS: Antennas, Tissues, Microwave radiation, Electromagnetism, 3D modeling, Tumors, Laser ablation, Cancer, Oncology, Numerical modeling

Read Abstract +

Proceedings Article | 12 March 2015 Paper

Development of a fast 3D treatment planning platform for clinical interstitial microwave hyperthermia within free-hand obliquely implanted HDR catheters

Serena Scott, Vasant Salgaonkar, Punit Prakash, Sergio Curto, I-Chow Hsu, Chris Diederich

Proceedings Volume 9326, 93260X (2015) https://doi.org/10.1117/12.2079701

KEYWORDS: Antennas, Tissues, 3D modeling, Superposition, Microwave radiation, Liquid crystals, High dynamic range imaging, Dielectrics, Blood, Distance measurement

Read Abstract +

A treatment planning platform for interstitial microwave hyperthermia was developed for practical, free-hand clinical implants. Such implants, consisting of non-parallel, moderately curved antennas with varying insertion depths, are used in HDR brachytherapy for treating locally advanced cancer.

Numerical models for commercially available MA251 antennas (915 MHz, BSD Medical) were developed in COMSOL Multiphysics, a finite element analysis software package. To expedite treatment planning, electric fields, power deposition and temperature rises were computed for a single straight antenna in 2D axisymmetric geometry. A precomputed library of electric field and temperature solutions was created for a range of insertion depths (5-12 cm) and blood perfusion rates (0.5-5 kg/m³/s). 3D models of multiple antennas and benchtop phantoms experiments using temperature-sensitive liquid crystal paper to monitor heating by curved antennas were performed for comparative evaluation of the treatment planning platform.

A patient-customizable hyperthermia treatment planning software package was developed in MATLAB with capabilities to interface with a commercial radiation therapy planning platform (Oncentra, Nucleotron), import patient and multicatheter implant geometries, calculate insertion depths, and perform hyperthermia planning with antennas operating in asynchronous or synchronous mode. During asynchronous operation, the net power deposition and temperature rises were approximated as a superposition sum of the respective quantities for one single antenna. During synchronous excitation, a superposition of complex electrical fields was performed with appropriate phasing to compute power deposition. Electric fields and temperatures from the pre-computed single-antenna library were utilized following appropriate non-rigid coordinate transformations. Comparison to 3D models indicated that superposition of electric fields around parallel antennas is valid when they are at least 15 mm apart. Phantom experiments with curved antennas produced temperature profiles quite similar to those created using the planning system.

The hyperthermia planning software allowed users to select power and phasing, assess the corresponding 3D contours of energy and temperature, and optimize treatment parameters through gradient search techniques. The system produces fairly accurate temperature distributions in cases when the antennas are at least 15 mm apart.

Proceedings Article | 12 March 2015 Paper

Design and analysis of a conformal patch antenna for a wearable breast hyperthermia treatment system

Sergio Curto, Manoshika Ramasamy, Minyoung Suh, Punit Prakash

Proceedings Volume 9326, 93260I (2015) https://doi.org/10.1117/12.2079718

KEYWORDS: Antennas, Tissues, Breast, Skin, Printing, Prototyping, Silver, Microwave radiation, Tumors, Dielectrics

Read Abstract +

To overcome the limitations of currently available clinical hyperthermia systems which are based on rigid waveguide antennas, a wearable microwave hyperthermia system is presented. A light wearable system can improve patient comfort and be located in close proximity to the breast, thereby enhancing energy deposition and reducing power requirements. The objective of this work was to design and assess the feasibility of a conformal patch antenna element of an array system to be integrated into a wearable hyperthermia bra. The feasibility of implementing antennas with silver printed ink technology on flexible substrates was evaluated. A coupled electromagnetic-bioheat transfer solver and a hemispheric heterogeneous numerical breast phantom were used to design and optimize a 915 MHz patch antenna. The optimization goals were device miniaturization, operating bandwidth, enhanced energy deposition pattern in targets, and reduced Efield back radiation. The antenna performance was evaluated for devices incorporating a hemispheric conformal groundplane and a rectangular groundplane configuration. Simulated results indicated a stable -10 dB return loss bandwidth of 88 MHz for both the conformal and rectangular groundplane configurations. Considering applied power levels restricted to 15 W, treatment volumes (T>41⁰C) and depth from the skin surface were 11.32 cm³ and 27.94 mm, respectively, for the conformal groundplane configuration, and 2.79 cm³ and 19.72 mm, respectively, for the rectangular groundplane configuration. E-field back-radiation reduced by 85.06% for the conformal groundplane compared to the rectangular groundplane configuration. A prototype antenna with rectangular groundplane was fabricatd and experimentally evaluated. The groundplane was created by printing silver ink (Metalon JS-B25P) on polyethylene terephthalate (PET) film surface. Experiments revealed stable antenna performance for power levels up to 15.3 W. In conclusion, the proposed patch antenna with conformal groundplane and prined ink technology shows promising performance to be integrated in a clinical array system.

Proceedings Article | 11 March 2015 Paper

Developing an open platform for evidence-based microwave ablation treatment planning and validation

Garron Deshazer, Damian Dupuy, Edward Walsh, Punit Prakash, Dillon Fairchild, David Glidden, Scott Collins, Madeleine Cook, Thomas Ryan, Derek Merck

Proceedings Volume 9326, 932605 (2015) https://doi.org/10.1117/12.2081216

KEYWORDS: Tissues, Liver, Tumors, Antennas, Microwave radiation, Thermal modeling, Dielectrics, Computed tomography, Data modeling, Temperature metrology

Read Abstract +

Proceedings Article | 26 February 2013 Paper

MR guided thermal therapy of pancreatic tumors with endoluminal, intraluminal and interstitial catheter-based ultrasound devices: preliminary theoretical and experimental investigations

Punit Prakash, Vasant Salgaonkar, Serena Scott, Peter Jones, Daniel Hensley, Andrew Holbrook, Juan Plata, Graham Sommer, Chris Diederich

Proceedings Volume 8584, 85840V (2013) https://doi.org/10.1117/12.2004669

KEYWORDS: Tumors, Ultrasonography, Tissues, Stomach, Magnetic resonance imaging, Transducers, Pancreas, Neodymium, 3D modeling, Acoustics

Read Abstract +

Image-guided thermal interventions have been proposed for potential palliative and curative treatments of pancreatic tumors. Catheter-based ultrasound devices offer the potential for temporal and 3D spatial control of the energy deposition profile. The objective of this study was to apply theoretical and experimental techniques to investigate the feasibility of endogastric, intraluminal and transgastric catheter-based ultrasound for MR guided thermal therapy of pancreatic tumors. The transgastric approach involves insertion of a catheter-based ultrasound applicator (array of 1.5 mm OD x 10 mm transducers, 360° or sectored 180°, ~7 MHz frequency, 13-14G cooling catheter) directly into the pancreas, either endoscopically or via image-guided percutaneous placement. An intraluminal applicator, of a more flexible but similar construct, was considered for endoscopic insertion directly into the pancreatic or biliary duct. An endoluminal approach was devised based on an ultrasound transducer assembly (tubular, planar, curvilinear) enclosed in a cooling balloon which is endoscopically positioned within the stomach or duodenum, adjacent to pancreatic targets from within the GI tract. A 3D acoustic bio-thermal model was implemented to calculate acoustic energy distributions and used a FEM solver to determine the transient temperature and thermal dose profiles in tissue during heating. These models were used to determine transducer parameters and delivery strategies and to study the feasibility of ablating 1-3 cm diameter tumors located 2-10 mm deep in the pancreas, while thermally sparing the stomach wall. Heterogeneous acoustic and thermal properties were incorporated, including approximations for tumor desmoplasia and dynamic changes during heating. A series of anatomic models based on imaging scans of representative patients were used to investigate the three approaches. Proof of concept (POC) endogastric and transgastric applicators were fabricated and experimentally evaluated in tissue mimicking phantoms, ex vivo tissue and in vivo canine model under multi-slice MR thermometry. RF micro-coils were evaluated to enable active catheter-tracking and prescription of thermometry slice positions. Interstitial and intraluminal ultrasound applicators could be used to ablate (t₄₃>240min) tumors measuring 2.3-3.4 cm in diameter when powered with 20-30 W/cm² at 7 MHz for 5-10 min. Endoluminal applicators with planar and curvilinear transducers operating at 3-4 MHz could be used to treat tumors up to 20-25 mm deep from the stomach wall within 5 min. POC devices were fabricated and successfully integrated into the MRI environment with catheter tracking, real-time thermometry and closed-loop feedback control.

Proceedings Article | 26 February 2013 Paper

Targeted hyperthermia in prostate with an MR-guided endorectal ultrasound phased array: patient specific modeling and preliminary experiments

Vasant Salgaonkar, Punit Prakash, Juan Plata, Andrew Holbrook, Viola Rieke, John Kurhanewicz, I-C. Hsu, Chris Diederich

Proceedings Volume 8584, 85840U (2013) https://doi.org/10.1117/12.2004609

KEYWORDS: Prostate, Phased arrays, Acoustics, Tissues, Ultrasonography, Tumors, Magnetic resonance imaging, Bone, Blood, 3D modeling

Read Abstract +

Proceedings Article | 26 February 2013 Paper

Interstitial ultrasound ablation of tumors within or adjacent to bone: Contributions of preferential heating at the bone surface

Serena Scott, Punit Prakash, Vasant Salgaonkar, Peter Jones, Richard Cam, Misung Han, Viola Rieke, E. Clif Burdette, Chris Diederich

Proceedings Volume 8584, 85840Z (2013) https://doi.org/10.1117/12.2002632

KEYWORDS: Bone, Tissues, Tumors, Ultrasonography, Natural surfaces, 3D modeling, Acoustics, Safety, Transducers, Lung

Read Abstract +

Proceedings Article | 24 February 2011 Paper

Hepatic ablation with multiple interstitial ultrasound applicators: initial ex vivo and computational studies

Punit Prakash, Vasant Salgaonkar, E. Clif Burdette, Chris Diederich

Proceedings Volume 7901, 79010R (2011) https://doi.org/10.1117/12.876522

KEYWORDS: Liver, Transducers, Ultrasonography, Tissues, In vivo imaging, Finite element methods, Tumors, Computer simulations, Microwave radiation, Antennas

Read Abstract +

Proceedings Article | 24 February 2011 Paper

Fast optimization and planning of clinical interstitial ultrasound hyperthermia using superposition and surrogate models of temperature distributions

Vasant Salgaonkar, Punit Prakash, Chris Diederich

Proceedings Volume 7901, 79010P (2011) https://doi.org/10.1117/12.876410

KEYWORDS: Superposition, Transducers, Ultrasonography, Optimization (mathematics), Finite element methods, 3D modeling, Prostate, Temperature metrology, Tissues, Blood

Read Abstract +

Proceedings Article | 23 February 2011 Paper

Catheter-based ultrasound hyperthermia with HDR brachytherapy for treatment of locally advanced cancer of the prostate and cervix

Chris Diederich, Jeff Wootton, Punit Prakash, Vasant Salgaonkar, Titania Juang, Serena Scott, Xin Chen, Adam Cunha, Jean Pouliot, I. Hsu

Proceedings Volume 7901, 79010O (2011) https://doi.org/10.1117/12.876401

KEYWORDS: Ultrasonography, High dynamic range imaging, Cervix, Prostate, Transducers, Computing systems, Control systems, Amplifiers, Thermometry, Rectum

Read Abstract +

A clinical treatment delivery platform has been developed and is being evaluated in a clinical pilot study for providing 3D controlled hyperthermia with catheter-based ultrasound applicators in conjunction with high dose rate (HDR) brachytherapy. Catheter-based ultrasound applicators are capable of 3D spatial control of heating in both angle and length of the devices, with enhanced radial penetration of heating compared to other hyperthermia technologies. Interstitial and endocavity ultrasound devices have been developed specifically for applying hyperthermia within HDR brachytherapy implants during radiation therapy in the treatment of cervix and prostate. A pilot study of the combination of catheter based ultrasound with HDR brachytherapy for locally advanced prostate and cervical cancer has been initiated, and preliminary results of the performance and heating distributions are reported herein. The treatment delivery platform consists of a 32 channel RF amplifier and a 48 channel thermocouple monitoring system. Controlling software can monitor and regulate frequency and power to each transducer section as required during the procedure. Interstitial applicators consist of multiple transducer sections of 2-4 cm length × 180 deg and 3-4 cm × 360 deg. heating patterns to be inserted in specific placed 13g implant catheters. The endocavity device, designed to be inserted within a 6 mm OD plastic tandem catheter within the cervix, consists of 2-3 transducers × dual 180 or 360 deg sectors. 3D temperature based treatment planning and optimization is dovetailed to the HDR optimization based planning to best configure and position the applicators within the catheters, and to determine optimal base power levels to each transducer section. To date we have treated eight cervix implants and six prostate implants. 100 % of treatments achieved a goal of >60 min duration, with therapeutic temperatures achieved in all cases. Thermal dosimetry within the hyperthermia target volume (HTV) and clinical target volume (CTV) are reported. Catheter-based ultrasound hyperthermia with HDR appears feasible with therapeutic temperature coverage of the target volume within the prostate or cervix while sparing surrounding more sensitive regions.

Proceedings Article | 12 March 2010 Paper

The ACUSITT ultrasonic ablator: the first steerable needle with an integrated interventional tool

E. Clif Burdette, D. Caleb Rucker, Punit Prakash, Chris Diederich, Jordon Croom, Clyde Clarke, Philipp Stolka, Titania Juang, Emad Boctor, Robert Webster

Proceedings Volume 7629, 76290V (2010) https://doi.org/10.1117/12.845972

KEYWORDS: Tissues, Liver, Ultrasonography, Ultrasonics, Tumors, Thermal modeling, Acoustics, Control systems, Kinematics, Transducers

Read Abstract +

Proceedings Article | 24 February 2009 Paper

Patient specific optimization-based treatment planning for catheter-based ultrasound hyperthermia and thermal ablation

Punit Prakash, Xin Chen, Jeffery Wootton, Jean Pouliot, I-Chow Hsu, Chris Diederich

Proceedings Volume 7181, 71810E (2009) https://doi.org/10.1117/12.809329

KEYWORDS: Ultrasonography, Tissues, Transducers, 3D modeling, Prostate, High dynamic range imaging, Thermal modeling, Bladder, Rectum, Cervix

Read Abstract +

A 3D optimization-based thermal treatment planning platform has been developed for the application of catheter-based ultrasound hyperthermia in conjunction with high dose rate (HDR) brachytherapy for treating advanced pelvic tumors. Optimal selection of applied power levels to each independently controlled transducer segment can be used to conform and maximize therapeutic heating and thermal dose coverage to the target region, providing significant advantages over current hyperthermia technology and improving treatment response. Critical anatomic structures, clinical target outlines, and implant/applicator geometries were acquired from sequential multi-slice 2D images obtained from HDR treatment planning and used to reconstruct patient specific 3D biothermal models. A constrained optimization algorithm was devised and integrated within a finite element thermal solver to determine a priori the optimal applied power levels and the resulting 3D temperature distributions such that therapeutic heating is maximized within the target, while placing constraints on maximum tissue temperature and thermal exposure of surrounding non-targeted tissue. This optimizationbased treatment planning and modeling system was applied on representative cases of clinical implants for HDR treatment of cervix and prostate to evaluate the utility of this planning approach. The planning provided significant improvement in achievable temperature distributions for all cases, with substantial increase in T90 and thermal dose (CEM43T90) coverage to the hyperthermia target volume while decreasing maximum treatment temperature and reducing thermal dose exposure to surrounding non-targeted tissues and thermally sensitive rectum and bladder. This optimization based treatment planning platform with catheter-based ultrasound applicators is a useful tool that has potential to significantly improve the delivery of hyperthermia in conjunction with HDR brachytherapy. The planning platform has been extended to model thermal ablation, including the addition of temperature dependent attenuation, perfusion, and tissue damage. Pilot point control at the target boundaries was implemented to control power delivery to each transducer section, simulating an approach feasible for MR guided procedures. The computer model of thermal ablation was evaluated on representative patient anatomies to demonstrate the feasibility of using catheter-based ultrasound thermal ablation for treatment of benign prostate hyperplasia (BPH) and prostate cancer, and to assist in designing applicators and treatment delivery strategies.

Showing 5 of 17 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years