Prof. Robert H. Wilson Profile

Prof. Robert H. Wilson

Assistant Professor of Physics at Univ of Dayton

SPIE Involvement:

Author

Publications (31)

SPIE Journal Paper | 15 February 2024 Open Access

Open Access

Review of machine learning for optical imaging of burn wound severity assessment

Robert H. Wilson, Rebecca Rowland, Gordon T. Kennedy, Chris Campbell, Victor C. Joe, Theresa L. Chin, David M. Burmeister, Robert J. Christy, Anthony J. Durkin

JBO, Vol. 29, Issue 02, 020901, (February 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.2.020901

KEYWORDS: Education and training, Tissues, Image classification, Optical imaging, Deep learning, Machine learning, Skin, Optical coherence tomography, Image segmentation, Multispectral imaging

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SPIE Journal Paper | 2 May 2023 Open Access

Open Access

Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer’s disease and neurological injury

Christian Crouzet, Thinh Phan, Robert H. Wilson, Teo Jeon Shin, Bernard Choi

NPh, Vol. 10, Issue 02, 020601, (May 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.020601

KEYWORDS: Hemodynamics, Optical imaging, Animal model studies, Brain, Tissues, Blood circulation, Speckle, Neurophotonics, Injuries, Optical properties

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Proceedings Article | 17 March 2023 Presentation

Presentation

Comparative evaluation of conventional color imaging and hyperspectral imaging data as inputs to machine learning algorithms for classifying burn severity

Samagra Pandey, Gordon Kennedy, Rebecca Rowland, Victor Joe, Theresa Chin, Robert Christy, David Burmeister, Robert Wilson, Anthony Durkin

Proceedings Volume PC12352, PC1235207 (2023) https://doi.org/10.1117/12.2664961

KEYWORDS: Machine learning, Color imaging, Hyperspectral imaging, Data modeling, Multispectral imaging, Digital color imaging, Diffuse optical imaging, Biopsy

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Proceedings Article | 6 March 2023 Presentation

Presentation

Characterizing and overcoming the confounding effects of skin pigmentation for improved quantification of tissue oxygenation and hemodynamic changes across all skin types

Robert Wilson, Gordon Kennedy, Thinh Phan, Wei Jin, Anthony Durkin

Proceedings Volume PC12375, PC1237506 (2023) https://doi.org/10.1117/12.2650525

KEYWORDS: Skin, Tissues, Hemodynamics, Tissue optics, Oxygen, Spatial frequencies, Oximeters, Natural surfaces, Monte Carlo methods, Mathematical modeling

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Proceedings Article | 3 October 2022 Presentation

Presentation

Optical signaling through biological waveguides

Nicolas Perez, Anna Bezryadina, Robert Wilson, Daryl Preece

Proceedings Volume PC12198, PC121980B (2022) https://doi.org/10.1117/12.2633316

KEYWORDS: Waveguides, Polarization, Biomedical optics, Light scattering, Scattering media, Scattering, Optical properties, Laser beam diagnostics, Blood, Wavefronts

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SPIE Journal Paper | 23 March 2022 Open Access

Open Access

Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: a comparison of colorimetry with spatial frequency domain imaging

Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh Le, Seyed Sharif, Gordon Kennedy, Robert Wilson, Anthony Durkin

JBO, Vol. 27, Issue 03, 036002, (March 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.3.036002

KEYWORDS: Skin, Tissue optics, Optical properties, Scattering, Absorption, Optical testing, Colorimetry, Tissues, Data modeling, Monte Carlo methods

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Significance: Spatial frequency domain imaging (SFDI) is a wide-field diffuse optical imaging technique for separately quantifying tissue reduced scattering (μs ′ ) and absorption (μa) coefficients at multiple wavelengths, providing wide potential utility for clinical applications such as burn wound characterization and cancer detection. However, measured μs ′ and μa can be confounded by absorption from melanin in patients with highly pigmented skin. This issue arises because epidermal melanin is highly absorbing for visible wavelengths and standard homogeneous light–tissue interaction models do not properly account for this complexity. Tristimulus colorimetry (which quantifies pigmentation using the L * “lightness” parameter) can provide a point of comparison between μa, μs ′ , and skin pigmentation. Aim: We systematically compare SFDI and colorimetry parameters to quantify confounding effects of pigmentation on measured skin μs ′ and μa. We assess the correlation between SFDI and colorimetry parameters as a function of wavelength. Approach: μs ′ and μa from the palm and ventral forearm were measured for 15 healthy subjects with a wide range of skin pigmentation levels (Fitzpatrick types I to VI) using a Reflect RS® (Modulim, Inc., Irvine, California) SFDI instrument (eight wavelengths, 471 to 851 nm). L * was measured using a Chroma Meter CR-400 (Konica Minolta Sensing, Inc., Tokyo). Linear correlation coefficients were calculated between L * and μs ′ and between L * and μa at all wavelengths. Results: For the ventral forearm, strong linear correlations between measured L * and μs ′ values were observed at shorter wavelengths (R > 0.92 at ≤659 nm), where absorption from melanin confounded the measured μs ′ . These correlations were weaker for the palm (R < 0.59 at ≤659 nm), which has less melanin than the forearm. Similar relationships were observed between L * and μa. Conclusions: We quantified the effects of epidermal melanin on skin μs ′ and μa measured with SFDI. This information may help characterize and correct pigmentation-related inaccuracies in SFDI skin measurements.

SPIE Journal Paper | 8 April 2021 Open Access

Open Access

High-speed quantitative optical imaging of absolute metabolism in the rat cortex

Robert Wilson, Christian Crouzet, Mohammad Torabzadeh, Afsheen Bazrafkan, Niki Maki, Bruce Tromberg, Yama Akbari, Bernard Choi

NPh, Vol. 8, Issue 02, 025001, (April 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.2.025001

KEYWORDS: Brain, Mode conditioning cables, Optical imaging, Oxygen, Ischemia, Tissue optics, Tissues, Positron emission tomography, Optical properties, Neuroimaging

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Proceedings Article | 5 March 2021 Presentation

Presentation

Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging

Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh Le, Robert Wilson, Seyed Sharif, Gordon Kennedy, Anthony Durkin

Proceedings Volume 11618, 1161810 (2021) https://doi.org/10.1117/12.2576800

KEYWORDS: Skin, Optical properties, In vivo imaging, Tissue optics, Scattering, Remote sensing, Range imaging, Monte Carlo methods, Mie scattering, Light wave propagation

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

An iterative method to quantify epidermal melanin concentration using spatial frequency domain Imaging and a layered Monte Carlo model

Wei Jin, Rebecca Rowland, Robert Wilson, Thinh Phan, Binh Cong Le, Gordon Kennedy, Anthony Durkin

Proceedings Volume 11618, 1161811 (2021) https://doi.org/10.1117/12.2579019

KEYWORDS: Skin, Monte Carlo methods, Iterative methods, Tissue optics, Reflectivity, Optical properties, Diffuse reflectance spectroscopy, Diffuse optical imaging, Absorption, Yield improvement

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Proceedings Article | 5 March 2021 Presentation

Presentation

Contributions of diffuse and directed flow in turbid media to absolute measurements of tissue perfusion and oxygen consumption using laser speckle and spatial frequency domain imaging

Robert Wilson, Christian Crouzet, Afsheen Bazrafkan, Masih Rafi, Yama Akbari, Bernard Choi

Proceedings Volume 11629, 116290E (2021) https://doi.org/10.1117/12.2579039

KEYWORDS: Speckle, Oxygen, Laser tissue interaction, Tissues, Blood circulation, Tissue optics, Scattering, Positron emission tomography, Optical properties, Monte Carlo methods

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SPIE Journal Paper | 10 February 2021 Open Access

Open Access

Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging

Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh Le, Robert Wilson, Seyed Sharif, Gordon Kennedy, Nicole Bernal, Anthony Durkin

JBO, Vol. 26, Issue 02, 026001, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.026001

KEYWORDS: Skin, Scattering, Optical properties, Absorption, In vivo imaging, Tissue optics, Wound healing, Tissues, Human subjects, Visible radiation

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Significance: Spatial frequency domain imaging (SFDI), a noncontact wide-field imaging technique using patterned illumination with multiple wavelengths, has been used to quantitatively measure structural and functional parameters of in vivo tissue. Using SFDI in a porcine model, we previously found that scattering changes in skin could potentially be used to noninvasively assess burn severity and monitor wound healing. Translating these findings to human subjects necessitates a better understanding of the variation in “baseline” human skin scattering properties across skin types and anatomical locations. Aim: Using SFDI, we aim to characterize the variation in the reduced scattering coefficient (μs′) for skin across a range of pigmentation and anatomic sites (including common burn locations) for normal human subjects. These measurements are expected to characterize baseline human skin properties to inform our use of SFDI for clinical burn severity and wound healing assessments. Approach: SFDI was used to measure μs′ in the visible- and near-infrared regime (471 to 851 nm) in 15 subjects at 10 anatomical locations. Subjects varied in age, gender, and Fitzpatrick skin type. Results: For all anatomical locations, the coefficient of variation in measured μs′ decreased with increasing wavelength. High intersubject variation in μs′ at visible wavelengths coincided with large values of the melanin extinction coefficient at those wavelengths. At 851 nm, where intersubject variation in μs′ was smallest for all anatomical locations and absorption from melanin is minimal, significant intrasubject differences in μs′ were observed at the different anatomical locations. Conclusions: Our study is the first report of wide-field mapping of human skin scattering properties across multiple skin types and anatomical locations using SFDI. Measured μs′ values varied notably between skin types at wavelengths where absorption from melanin was prominent. Additionally, μs′ varied considerably across different anatomical locations at 851 nm, where the confounding effects from melanin absorption are minimized.

Proceedings Article | 14 March 2018 Open Access

Open Access

Presentation

Global cerebral ischemia induces spatial propagation of cerebral blood flow during cardiac arrest and after resuscitation (Conference Presentation)

Christian Crouzet, Robert Wilson, Afsheen Bazrafkan, Juan Alcocer, Bruce Tromberg, Yama Akbari, Bernard Choi

Proceedings Volume 10481, 1048110 (2018) https://doi.org/10.1117/12.2291043

KEYWORDS: Brain, Ischemia, Cerebral blood flow, Speckle, Laser speckle imaging, Cranial windows

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SPIE Journal Paper | 26 December 2017 Open Access

Open Access

High-speed spatial frequency domain imaging of rat cortex detects dynamic optical and physiological properties following cardiac arrest and resuscitation

Robert Wilson, Christian Crouzet, Mohammad Torabzadeh, Afsheen Bazrafkan, Maryam Hosseini-Farahabadi, Babak Jamasian, Dishant Donga, Juan Alcocer, Shuhab Mohammed Zaher, Bernard Choi, Yama Akbari, Bruce Tromberg

NPh, Vol. 4, Issue 04, 045008, (December 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.4.045008

KEYWORDS: Scattering, Tissues, Brain, Tissue optics, Absorption, Cameras, Heart, Spatial frequencies, Oxygen, Light emitting diodes

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SPIE Journal Paper | 12 November 2015 Open Access

Open Access

Hyperspectral optical tomography of intrinsic signals in the rat cortex

Soren Konecky, Robert Wilson, Nathan Hagen, Amaan Mazhar, Tomasz Tkaczyk, Ron Frostig, Bruce Tromberg

NPh, Vol. 2, Issue 04, 045003, (November 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.4.045003

KEYWORDS: Tomography, Hemodynamics, Optical tomography, Monte Carlo methods, Tissues, 3D image processing, Hyperspectral imaging, Sensors, Absorption, Reconstruction algorithms

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SPIE Journal Paper | 24 March 2015 Open Access

Open Access

Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization

Robert Wilson, Kyle Nadeau, Frank Jaworski, Bruce Tromberg, Anthony Durkin

JBO, Vol. 20, Issue 03, 030901, (March 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.3.030901

KEYWORDS: Short wave infrared radiation, Absorption, Tissues, Tissue optics, Imaging spectroscopy, Scattering, Skin, In vivo imaging, Reflectivity, Near infrared

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SPIE Journal Paper | 13 August 2014 Open Access

Open Access

Quantitative short-wave infrared multispectral imaging of in vivo tissue optical properties

Robert Wilson, Kyle Nadeau, Frank Jaworski, Rebecca Rowland, John Quan Nguyen, Christian Crouzet, Rolf Saager, Bernard Choi, Bruce Tromberg, Anthony Durkin

JBO, Vol. 19, Issue 08, 086011, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086011

KEYWORDS: Short wave infrared radiation, Scattering, Absorption, Tissue optics, Optical properties, In vivo imaging, Tissues, Multispectral imaging, Infrared imaging, Infrared radiation

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Proceedings Article | 27 February 2014 Paper

Paper

Photon-tissue interaction model for quantitative assessment of biological tissues

Seung Yup Lee, William Lloyd, Robert Wilson, Malavika Chandra, Barbara McKenna, Diane Simeone, James Scheiman, Mary-Ann Mycek

Proceedings Volume 8935, 893528 (2014) https://doi.org/10.1117/12.2046980

KEYWORDS: Tissues, Reflectivity, Performance modeling, Scattering, Tumor growth modeling, Biological research, Tissue optics, Absorption, Data modeling, Pancreatic cancer

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SPIE Journal Paper | 1 July 2011 Open Access

Open Access

Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation

Matthew Keller, Elizabeth Vargis, Anita Mahadevan-Jansen, Nara de Matos Granja, Robert Wilson, Mary-Ann Mycek, Mark Kelley

JBO, Vol. 16, Issue 07, 077006, (July 2011) https://doi.org/10.1117/12.10.1117/1.3600708

KEYWORDS: Tumors, Tissues, Breast, Raman spectroscopy, Signal to noise ratio, Sensors, Natural surfaces, Tissue optics, Composites, Monte Carlo methods

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Proceedings Article | 15 June 2011 Paper

Paper

Mesh-based Monte Carlo code for fluorescence modeling in complex tissues with irregular boundaries

Robert Wilson, Leng-Chun Chen, William Lloyd, Shiuhyang Kuo, Cynthia Marcelo, Stephen Feinberg, Mary-Ann Mycek

Proceedings Volume 8090, 80900E (2011) https://doi.org/10.1117/12.889718

KEYWORDS: Tissues, Luminescence, Monte Carlo methods, Interfaces, Signal detection, Natural surfaces, MATLAB, Fluorescence spectroscopy, Photon transport, Nonlinear optics

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Proceedings Article | 15 June 2011 Paper

Paper

Nonlinear optical molecular imaging enables metabolic redox sensing in tissue-engineered constructs

Leng-Chun Chen, William Lloyd, Robert Wilson, Shiuhyang Kuo, Cynthia Marcelo, Stephen Feinberg, Mary-Ann Mycek

Proceedings Volume 8089, 80890J (2011) https://doi.org/10.1117/12.889713

KEYWORDS: Luminescence, Collagen, Molecular imaging, Tissues, Tissue optics, Second-harmonic generation, Image processing, Calcium, Mode conditioning cables, Interfaces

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Proceedings Article | 10 June 2011 Paper

Paper

Optical spectroscopy for quantitative sensing in human pancreatic tissues

Robert Wilson, Malavika Chandra, William Lloyd, Leng-Chun Chen, James Scheiman, Diane Simeone, Barbara McKenna, Mary-Ann Mycek

Proceedings Volume 8087, 808713 (2011) https://doi.org/10.1117/12.889724

KEYWORDS: Reflectivity, Tissues, Luminescence, Optical spectroscopy, Collagen, Diagnostics, Fluorescence spectroscopy, Biomedical optics, Cancer, Pancreas

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Proceedings Article | 9 June 2011 Paper

Paper

Fluorescence wavelength-time matrix acquisition for biomedical tissue diagnostics

William Lloyd, Robert Wilson, Leng-Chun Chen, Gregory Gillispie, Mary-Ann Mycek

Proceedings Volume 8087, 80870Y (2011) https://doi.org/10.1117/12.889649

KEYWORDS: Tissues, Luminescence, Diagnostics, Biomedical optics, Rhodamine, Scattering, Fiber optics, Signal to noise ratio, Tissue optics, Fluorescence spectroscopy

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SPIE Journal Paper | 1 May 2010 Open Access

Open Access

Quantitative polarized Raman spectroscopy in highly turbid bone tissue

Mekhala Raghavan, Nadder Sahar, Robert Wilson, Mary-Ann Mycek, Nancy Pleshko, David Kohn, Michael Morris

JBO, Vol. 15, Issue 03, 037001, (May 2010) https://doi.org/10.1117/12.10.1117/1.3426310

KEYWORDS: Bone, Raman spectroscopy, Minerals, Collagen, Crystals, Tissue optics, Raman scattering, Scattering, Objectives, Tissues

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Proceedings Article | 3 March 2010 Paper

Paper

Polarized Raman spectroscopy of bone tissue: watch the scattering

Mekhala Raghavan, Nadder Sahar, Robert Wilson, Mary-Ann Mycek, Nancy Pleshko, David Kohn, Michael Morris

Proceedings Volume 7548, 754848 (2010) https://doi.org/10.1117/12.841977

KEYWORDS: Raman spectroscopy, Bone, Light scattering, Scattering, Tissue optics, Raman scattering, Minerals, Objectives, Polarization, Crystals

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Proceedings Article | 20 February 2010 Paper

Paper

Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media

Ching-Wei Chang, William Lloyd, Robert Wilson, Gregory Gillispie, Mary-Ann Mycek

Proceedings Volume 7555, 755503 (2010) https://doi.org/10.1117/12.845789

KEYWORDS: Luminescence, Collagen, Tissues, Monte Carlo methods, Scattering, Fluorescence spectroscopy, Data acquisition, Fiber optics, Matrices, Biomedical optics

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Proceedings Article | 8 July 2009 Paper

Paper

Optical spectroscopy for clinical detection of pancreatic cancer

Malavika Chandra, Robert Wilson, James Scheiman, Diane Simeone, Barbara McKenna, Julianne Purdy, Mary-Ann Mycek

Proceedings Volume 7368, 73681G (2009) https://doi.org/10.1117/12.831633

KEYWORDS: Reflectivity, Luminescence, Tissues, Tissue optics, Pancreatic cancer, Chemometrics, Optical spectroscopy, Fluorescence spectroscopy, Diagnostics, Algorithm development

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Proceedings Article | 25 February 2009 Paper

Paper

Mathematical modeling of reflectance and intrinsic fluorescence for cancer detection in human pancreatic tissue

Robert Wilson, Malavika Chandra, James Scheiman, Diane Simeone, Barbara McKenna, Julianne Purdy, Mary-Ann Mycek

Proceedings Volume 7187, 71870H (2009) https://doi.org/10.1117/12.809243

KEYWORDS: Reflectivity, Luminescence, Tissues, Absorption, Mathematical modeling, Pancreatic cancer, Tissue optics, Cancer, Fluorescence spectroscopy, Diagnostics

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Proceedings Article | 25 February 2009 Paper

Paper

Combined Monte Carlo and path-integral method for simulated library of time-resolved reflectance curves from layered tissue models

Robert Wilson, Karthik Vishwanath, Mary-Ann Mycek

Proceedings Volume 7175, 717518 (2009) https://doi.org/10.1117/12.808423

KEYWORDS: Tissue optics, Tissues, Reflectivity, Monte Carlo methods, Absorption, Scattering, Photon transport, Computer simulations, Mathematical modeling, Astronomical imaging

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Proceedings Article | 18 February 2009 Paper

Paper

Monte Carlo modeling of photon transport in buried bone tissue layer for quantitative Raman spectroscopy

Robert Wilson, Kathryn Dooley, Michael Morris, Mary-Ann Mycek

Proceedings Volume 7166, 716604 (2009) https://doi.org/10.1117/12.808417

KEYWORDS: Bone, Tissues, Raman scattering, Raman spectroscopy, Signal detection, Tissue optics, Scattering, Reflectivity, Absorption, Monte Carlo methods

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Proceedings Article | 19 July 2007 Paper

Paper

Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models

Robert Wilson, Karthik Vishwanath, Mary-Ann Mycek

Proceedings Volume 6628, 66280W (2007) https://doi.org/10.1117/12.729431

KEYWORDS: Tissues, Reflectivity, Absorption, Tissue optics, Monte Carlo methods, Computer simulations, Scattering, Photon transport, Optical properties, Anisotropy

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Proceedings Article | 11 July 2007 Paper

Paper

Sensing metabolic activity in tissue engineered constructs

Malavika Chandra, Robert Wilson, Wen-Liang Lo, Karthik Vishwanath, Kenji Izumi, Stephen Feinberg, Mary-Ann Mycek

Proceedings Volume 6628, 66280B (2007) https://doi.org/10.1117/12.729426

KEYWORDS: Luminescence, Tissues, Monte Carlo methods, Collagen, Signal detection, Sensors, Tissue optics, Fluorescence spectroscopy, Absorption, Natural surfaces

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Showing 5 of 31 publications

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