Liquid metal nanoparticles, particularly Eutectic Gallium Indium (EGaIn), hold great potential in medical applications such as biosensors, bioelectrodes, cancer treatment, and medical imaging. This study focuses on the synthesis of EGaIn nanoparticles using sonication without harsh chemicals. The nanoparticles are surface functionalized with hyaluronan and the photosensitizer benzoporphyrin derivative (BPD) for photodynamic therapy. EGaIn nanoparticles exhibit stability, good biocompatibility, and high optical absorption for photoacoustic imaging. The singlet oxygen generation of EGaPs is compared with free BPD under physiological conditions. Additionally, in vitro and in vivo investigations confirm the photodynamic efficacy of EGaPs, making them versatile nanoparticles for targeting, imaging, drug delivery, and photodynamic therapy
This Conference Presentation, “Eutectic gallium-indium alloy based liquid metal nanoparticles for photoacoustic imaging and photodynamic therapy,” was recorded at SPIE Photonics West 2022 held in San Francisco, California, United States.
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