Ms. Shera Fisk Profile

Shera Fisk

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 14 February 2020 Paper

Using near-infrared spectroscopy to monitor spinal cord oxygenation in the injured spinal cord

A. Cheung, L. Tu, N. Manouchehri, K. T. Kim, K. So, M. Webster, S. Fisk, S. Tigchelaar, S. Dalkilic, F. Streijger, A. Macnab, B. Kwon, B. Shadgan

Proceedings Volume 11247, 1124709 (2020) https://doi.org/10.1117/12.2546577

KEYWORDS: Near infrared spectroscopy, Spinal cord, Sensors, Injuries, Tissues, Oxygen, Tissue optics, Hemodynamics, Hypoxia, Surgery

Read Abstract +

Introduction: Current clinical guidelines recommend augmenting the mean arterial pressure (MAP) in acute spinal cord injury (SCI) patients to increase perfusion and oxygen delivery to the spinal cord, and potentially improve neurologic function. However, it is difficult for clinicians to hemodynamically manage acute SCI patients without real-time physiologic information about the effect of MAP augmentation within the injured cord. In this study, we investigated the utilization of a customized optical sensor, based on near-infrared spectroscopy (NIRS), to non-invasively monitor spinal cord oxygenation during the first week post-injury in a porcine model. Methods: Six Yucatan mini-pigs received a weight-drop T10 contusion-compression injury. A multi-wavelength NIRS system with a custom-made miniaturized sensor was placed directly onto the dura. The spinal cord tissue oxygenation index (TOI) and concentrations of oxygenated, deoxygenated, and total hemoglobin were monitored before and after SCI. To validate the NIRS measures, invasive intraparenchymal (IP) combined PO2/blood flow sensors were inserted into the spinal cord adjacent to the NIRS sensor. Episodes of MAP alteration and hypoxia were performed acutely after injury, 2 days post-injury, and 7 days post-injury to simulate the types of hemodynamic changes SCI patients experience post-injury. Results: Non-invasive NIRS monitoring identified changes in spinal cord oxygenation levels during the MAP alterations. Changes of TOI followed similar patterns of IP-derived oxygenation changes. Conclusion: Our novel NIRS sensor is feasible as a non-invasive technique to monitor real-time changes in spinal cord oxygenation 7 days post-injury in a porcine model of SCI.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years