We demonstrate that incorporating Förster resonant energy transferring (FRET) mechanism to the Whispering gallery mode (WGM) microcavity can greatly enhance the sensitivity. A donor-dye doped microsphere is embedded in an acceptor dye solution, which forms a FRET-WGM sensing platform. Pumping the WGM microcavity with a pulsed laser, we obtained simultaneous lasing of donor and acceptor dyes. The gap between donor and acceptor resonant wavelengths serves as a readout for acceptor quantification. Compared with the pure WGMs sensing system, the detection limit of FRET-WGM is greatly decreased, which enables us to realize real-time monitoring and quantitative analysis of intracellular fluorescent substance at single cell level.
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