Prof. Sol Kimel Profile

Prof. Sol Kimel

Professor Emeritus at Technion-Israel Institute of Technology

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Author

Publications (18)

Proceedings Article | 16 November 2000 Paper

Noninvasive tumor detection using spectrally-resolved in-vivo imaging

Gennady Kostenich, Sol Kimel, Zvi Malik, Arie Orenstein

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409335

KEYWORDS: Melanoma, Reflectivity, Skin, Tumors, Luminescence, Imaging spectroscopy, Imaging systems, Tissue optics, In vivo imaging, Near infrared

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Proceedings Article | 22 December 1997 Paper

Cryogen spray cooling of human skin: effects of ambient humidity level, spraying distance, and cryogen boiling point

Bahman Anvari, Benjamin Ver Steeg, Thomas Milner, B. Tanenbaum, Travis Klein, Eliot Gerstner, Sol Kimel, J. Stuart Nelson

Proceedings Volume 3192, (1997) https://doi.org/10.1117/12.297833

KEYWORDS: Cryogenics, Skin, Humidity, Injuries

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Proceedings Article | 22 September 1997 Paper

Photodynamic damage to cartilage and synovial tissue grafted on a chick chorioallantoic membrane

M. Fisher, A. Nahir, Sol Kimel

Proceedings Volume 3110, (1997) https://doi.org/10.1117/12.281329

KEYWORDS: Cartilage, Content addressable memory, Photodynamic therapy, Tissues, Collagen, Tissue optics, Blood vessels, Magnesium, Luminescence, Absorbance

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Proceedings Article | 23 May 1997 Open Access

Cell damage in UVA and cw/femtosecond NIR microscopes

Karsten Koenig, Hong Liang, Sol Kimel, Lars Svaasand, Bruce Tromberg, Tatiana Krasieva, Michael Berns, Karl-Juergen Halbhuber, Peter So, William Mantulin, Enrico Gratton

Proceedings Volume 2983, (1997) https://doi.org/10.1117/12.274337

KEYWORDS: Near infrared, Femtosecond phenomena, Microscopes, Continuous wave operation, Luminescence, Objectives, Absorption, Optical tweezers, Microscopy, Cell death

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Proceedings Article | 3 December 1996 Paper

Cryogen spray cooling for spatially selective photocoagulation: a feasibility study with potential application for treatment of hemangiomas

Bahman Anvari, B. Tanenbaum, Thomas Milner, Wendy Hoffman, Samireh Said, Cheng-Jen Chang, Lih-Huei Liaw, Sol Kimel, J. Stuart Nelson

Proceedings Volume 2922, (1996) https://doi.org/10.1117/12.260697

KEYWORDS: Tissues, Cryogenics, Natural surfaces, Nd:YAG lasers, Temperature metrology, Laser coagulation, Laser irradiation, Injuries, Blood vessels, Infrared radiation

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Proceedings Article | 31 January 1996 Paper

Photodynamic activity of porphines on tubulin assembly

Israel Ringel, Varda Gottfried, Lila Levdansky, James Winkelman, Sol Kimel

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230982

KEYWORDS: Analog electronics, Photodynamic therapy, Polymers, Additive manufacturing, Proteins, In vitro testing, Tissues, Cancer, Polymerization, Electron microscopy

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Porphyrins and porphine analogs have been shown to induce cytotoxic effects on cells and tissues after exposure to light, an effect which is currently being studied as a new modality for treatment of cancer, termed photodynamic therapy (PDT). One of the important factors in PDT is the preferential uptake of sensitizers by rapidly proliferating tissues. Previous studies showed that cytoskeletal structures are affected by porphyrin-induced PDT. In the present study we investigate the inhibitory efficiency of porphines on tubulin assembly in vitro. We analyze the efficiency of several sulfonated porphine isomers: tetraphenylporphine n-sulfonate (TPPS_n) where n equals 4, 2a and 2o (a and o refer to adjacent and opposite substitution, respectively) and the structural isomers of tetra(o-,m-, and p-hydroxyphenyl)porphine (o-,m- ,p-THPP), in order to find a possible structure-activity relationship. The efficiency of the sensitizers was assayed by their capacity to inhibit microtubule assembly. Binding to monomeric tubulin is essential for effective inhibition of assembly, with or without exposure to light. Without exposure to light, TPPS_2o was found to be the most potent inhibitor, followed by TPPS_2a and to a much smaller extent by TPPS₄. All THPP isomers have negligible inhibitory effect. Upon exposure to white light, microtubule assembly was inhibited in the same order:TPPS_2o greater than TPPS_2a greater than TPPS₄ greater than THPP. All porphines were found to have high affinity to the same site on tubulin even those who had almost no dark effect on tubulin assembly (THPP). Addition of the porphines to assembled microtubules did not lead to their depolymerization even after prolonged irradiation. Since it was previously suggested that porphines may share the same binding site on tubulin as bis-ANS, a known tubulin assembly inhibitor, we performed competition studies with this inhibitor and the porphines. It was shown that bis-ANS does not share the same site on tubulin as the porphines and therefore their effects are additive.

Proceedings Article | 31 January 1996 Paper

Uptake and photodynamic activity of porphycenes in tumor cells implanted on the chick chorioallantoic membrane (CAM)

Ronit Davidi, Varda Gottfried, Sol Kimel

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230977

KEYWORDS: Tumors, Content addressable memory, Photodynamic therapy, Luminescence, Blood vessels, In vivo imaging, Video, Injuries, Blood, Melanoma

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Proceedings Article | 19 January 1996 Paper

Epidermal cooling during pulsed laser treatment of selected dermatoses

J. Stuart Nelson, Bahman Anvari, B. Tanenbaum, Thomas Milner, Sol Kimel, Lars Svaasand

Proceedings Volume 2623, (1996) https://doi.org/10.1117/12.230299

KEYWORDS: Skin, Cryogenics, Temperature metrology, Injuries, Blood vessels, Laser irradiation, Laser therapeutics, Blood, Absorption, Infrared radiation

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Proceedings Article | 15 January 1996 Paper

Real-time fluorescence microscopy monitoring of porphyrin biodistribution

Sol Kimel, Varda Gottfried, Karin Kunzi-Rapp, Nermin Akguen, Herbert Schneckenburger

Proceedings Volume 2628, (1996) https://doi.org/10.1117/12.229978

KEYWORDS: Luminescence, Content addressable memory, Tissues, Microscopy, Photodynamic therapy, In vivo imaging, Video, Blood vessels, Veins, Time metrology

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Proceedings Article | 1 February 1995 Paper

Photodynamic effects on human and chicken erythrocytes

Sol Kimel, Karsten Koenig, Michael Berns

Proceedings Volume 2329, (1995) https://doi.org/10.1117/12.200891

KEYWORDS: Luminescence, Confocal microscopy, Photodynamic therapy, Blood, Microscopy, Tumors, Laser scanners, Molecules, Proteins, Quantum efficiency

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Proceedings Article | 18 January 1995 Paper

Epidermal heating during laser-induced photothermolysis of port wine stains: modeling melanosomal heating after dynamic cooling of the skin surface

Lars Svaasand, Thomas Milner, Bahman Anvari, Lill Norvang Nilsen, B. Tanenbaum, Sol Kimel, Michael Berns, J. Stuart Nelson

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199218

KEYWORDS: Skin, Cryogenics, Pulsed laser operation, Absorption, Temperature metrology, Diffusion, Blood vessels, Blood, Spherical lenses, Tissues

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Proceedings Article | 1 March 1994 Paper

In vivo uptake and photodynamic activity of porphycenes

Sol Kimel, Varda Gottfried, Ronit Davidi, Claudia Averbuj

Proceedings Volume 2078, (1994) https://doi.org/10.1117/12.168654

KEYWORDS: Content addressable memory, Tumors, Photodynamic therapy, Luminescence, In vivo imaging, Blood vessels, Absorption, Cancer, Absorbance, Tissues

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Proceedings Article | 1 February 1994 Paper

Video microscopy of vascular damage during PDT

Sol Kimel, Varda Gottfried

Proceedings Volume 2083, (1994) https://doi.org/10.1117/12.167425

KEYWORDS: Tumors, Photodynamic therapy, Content addressable memory, Image analysis, Blood vessels, Video, Image processing, Video processing, In vivo imaging, Edge detection

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Proceedings Article | 1 February 1994 Paper

Laser photothermolysis of single blood vessels in the chick chorioallantoic membrane (CAM)

Sol Kimel, Lars Svaasand, Thomas Milner, Marie Hammer-Wilson, Michael Schell, J. Stuart Nelson, Michael Berns

Proceedings Volume 2077, (1994) https://doi.org/10.1117/12.168033

KEYWORDS: Content addressable memory, Blood vessels, Absorption, Capillaries, Thermal effects, Blood, Pulsed laser operation, Diffusion, Laser irradiation, Injuries

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Proceedings Article | 1 November 1991 Paper

Chick chorioallantoic membrane for the study of synergistic effects of hyperthermia and photodynamic therapy

Sol Kimel, Lars Svaasand, Marie Hammer-Wilson, Varda Gottfried, Michael Berns

Proceedings Volume 1525, (1991) https://doi.org/10.1117/12.48197

KEYWORDS: Content addressable memory, Photodynamic therapy, Blood, Luminescence, Tumors, Carbon dioxide lasers, In vivo imaging, Biomedical optics, Laser therapeutics, Blood vessels

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The chick chorioallantoic membrane (CAM) model was used to study synergistic effects of photodynamic therapy (PDT) and hyperthermia (HPT). Since HPT is known, and PDT is believed, to involve a vascular mechanism, the CAM is an ideal medium to study the synergism of these modalities. Moreover, the CAM is a particularly convenient model to manipulate the PDT and HPT parameters and to monitor the modifications of the vasculature: (1) It is possible to view individual blood vessels in the CAM and to examine structural changes in real time. (2) The CAM is a closed system in which HPT can be performed quantitatively and to a selected depth, using different lasers. And (3) variations of surface temperature during PDT + HPT can be readily monitored by noninvasive radiometric techniques. A porphyrin-type photosensitizer solution was applied to areas of the CAM, defined by teflon O-rings placed on the surface. Uptake of the sensitizer into the CAM was determined by monitoring its fluorescence. Excitation light at 405 nm from a spectrofluorometer was directed onto the CAM surface using a bifurcated fiberoptic light guide which also transmitted the fluorescence from the CAM area. The fluorescence-emission spectrum (630-730 nm) and intensity at different times following sensitizer application was measured in vivo. This technique permitted the determination of the uptake dynamics of the sensitizer in the CAM and the establishment of the optimal time for irradiation. After an equilibrium time of 30 minutes, to allow for uptake of sensitizer in the CAM, the area was irradiated with a dual-wavelength system composed of a dye laser at 644 nm (to induce PDT) and a CO2 laser at 10.6 micrometers (to bring about HPT). Damage to the CAM vasculature, due to combined PDT + HPT, was compared to the outcome of the separate modalities. The observed synergistic effect of about 30 was interpreted by invoking various physiological processes. The egg, being a closed in vivo system, lends itself to mathematical modeling of the temporal and spatial temperature profile. The importance of heat dissipation due to diffusion, radiation, and blood perfusion was shown to be small compared to that of heat dissipation due to evaporation of water from the CAM.

Proceedings Article | 1 April 1991 Paper

Laser photodynamic therapy of cancer: the chorioallantoic membrane model for measuring damage to blood vessels in-vivo

Varda Gottfried, Ella Lindenbaum, Sol Kimel, Marie Hammer-Wilson, Michael Berns

Proceedings Volume 1442, (1991) https://doi.org/10.1117/12.49039

KEYWORDS: Content addressable memory, Tumors, Blood vessels, Photodynamic therapy, In vivo imaging, Control systems, Optical engineering, Luminescence, Cancer, Light sources

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Proceedings Article | 1 June 1990 Open Access

Monitoring the efficiency of photodynamic therapy in tissue

Arie Orenstein, Sol Kimel, Bruce Tromberg, J. Stuart Nelson, Michael Berns

Proceedings Volume 1202, (1990) https://doi.org/10.1117/12.17614

KEYWORDS: Oxygen, Photodynamic therapy, Tumors, Tissue optics, Electrodes, Ear, Laser tissue interaction, Skin, Blood vessels, Tissues

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Proceedings Article | 1 June 1990 Paper

Photodynamic therapy of hypervascular cutaneous tissues in animal models using porphyrin or phthalocyanine activated by red light

J. Stuart Nelson, Arie Orenstein, Lih-Huei Liaw, Sol Kimel, Michael Berns

Proceedings Volume 1200, (1990) https://doi.org/10.1117/12.17453

KEYWORDS: Photodynamic therapy, Laser therapeutics, Tissues, Tumors, Animal model studies, Blood vessels, Photosensitizer targeting, Dye lasers, Photography, Systems modeling

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Showing 5 of 18 publications

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