We have investigated the application of narrow-band intracavity spectroscopy for high throughput characterization and
detection of reaction products in-situ. An external cavity diode laser (ECDL), tunable from 810-890 nm, is used to
measure varying concentrations of a range of compounds in solution. A linear calibration curve for parts per billion (ppb)
concentrations corresponding to 17 nM has been achieved, levels not detectable with UV/VIS spectrometers. By
replacing the grating with a high reflective mirror, parts per trillion (ppt) concentration detection was also achieved
corresponding to 340 pM. We believe that this technique provides a method for fast and safe measurements of reactions
in real time and has potential applications in the pharmaceutical and chemical industry as well as for integrated bio-diagnostics
lab-on-a-chip devices.
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