Prof. William R. Wagner Profile

Prof. William R. Wagner

at Univ. of Pittsburgh Medical Ctr.

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 9 May 2024 Presentation + Paper

A novel in situ hemocompatibility enhancement in endovascular devices through arterial pulsation-driven surface modification

Mohamed Ibrahim, Sang-Ho Ye, William Wagner, Youngjae Chun

Proceedings Volume 12948, 1294803 (2024) https://doi.org/10.1117/12.3009999

KEYWORDS: Scanning electron microscopy, Blood, Arteries, Piezoelectric materials, Biological samples, In vitro testing, Batteries, Particles, Heart, Energy harvesting

Read Abstract +

Small artery-related diseases affecting coronary, cerebral, or peripheral regions remain a persistent clinical challenge, primarily due to the enduring risk of thrombosis associated with implanted vascular devices. Despite advances in therapeutic strategies, including the utilization of drug-eluting stents (DES), life-threatening complications, such as late thrombosis, continue to affect patients, leading to severe consequences like heart attacks, strokes, and pulmonary embolisms. To address this critical issue, an innovative in-situ piezoelectric material-based surface treatment system that utilizes arterial pulsation has been studied to treat the surface using arterial pulsation actively and continuously for indwelling endovascular devices. Our novel technology leverages piezoelectric materials to generate a negatively charged surface using arterial pulsation without any battery, actively and effectively repelling platelets adherence to prevent potential clot formation. Hence, substantial reduction in platelet adherence is expected to significantly lower the risk of thrombosis. In this study, a low-profile piezoelectric unit was fabricated and mounted on the coronary artery stent to be deployed and continuously exposed to the blood to assess the device hemocompatibility response, considering typical arterial pulsation, and both circumferential and radial deformation of the endovascular devices. Given the feasibility of achieving platelet-repelling voltages, the pulsation based piezoelectric system presents a promising solution for reducing the platelet adherence in indwelling endovascular devices without the need for passive coating or batteries, which enhances the overall effectiveness of endovascular devices.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years