Au nanostructures that exhibit strong localized surface plasmon resonance (SPR) have excellent potential for photo-medicine,
among a host of other applications. Here, we report the synthesis and use of colloidal gold nanorings (GNRs)
with potential for enhanced photodynamic therapy of cancer. The GNRs were fabricated via galvanic replacement
reaction of sacrificial Co nanoparticles in gold salt solution with low molecular weight (Mw = 2,500)
poly(vinylpyrrolidone) (PVP) as a stabilizing agent. The size and the opening of the GNRs were controlled by the size of
the starting Co particles and the concentration of the gold salt. UV-Vis absorption measurements indicated the tunability
of the SPR of the GNRs from 560 nm to 780 nm. MTT assay showed that GNRs were non-toxic and biocompatible
when incubated with breast cancer cells as well as the healthy counterpart cells. GNRs conjugated with 5-aminolevulinic
acid (5-ALA) photosensitizer precursor led to elevated formation of reactive oxygen species and improved efficacy of
photodynamic therapy of breast cancer cells under light irradiation compared to 5-ALA alone. These results can be
attributed to significantly enhance localized electromagnetic field of the GNRs.
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