Optoelectronic method for identifying fentanyl and the main metabolite norfentanyl

Raluca-Andreea Băjănaru; Georgeta-Marcela Bican; Jeni-Carla Colev; Ruxandra Populeanu; Marian Vlădescu; Paul Schiopu; Elena Truţă; Mihai Ionică

doi:10.1117/12.2324552

31 December 2018 Optoelectronic method for identifying fentanyl and the main metabolite norfentanyl

Raluca-Andreea Băjănaru, Georgeta-Marcela Bican, Jeni-Carla Colev, Ruxandra Populeanu, Marian Vlădescu, Paul Schiopu, Elena Truţă, Mihai Ionică

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Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 109773E (2018) https://doi.org/10.1117/12.2324552
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

This article highlights using liquid chromatography and the MRM method [1], the presence of fentanyl and norfentanyl [2] in a biological sample, in this case urine. In the method you can see the presence of each segment in the ion of the substance, obtained by ElectroSpray ionization [1], for which the confirmation is desired. The time of acquisition and the potential collision used to obtain it are specified.

The MRM method is performed with a varying concentration gradient of between 10% and 65% [3] over a 9 minute acquisition time at a constant flow rate of 0.3 ml / minute. The gradient increases from 10% to 40% in the first two minutes, then increases from 40% to 65% over the next 3 minutes. The 65% concentration remains for the next 4 minutes.

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Raluca-Andreea Băjănaru, Georgeta-Marcela Bican, Jeni-Carla Colev, Ruxandra Populeanu, Marian Vlădescu, Paul Schiopu, Elena Truţă, and Mihai Ionică "Optoelectronic method for identifying fentanyl and the main metabolite norfentanyl", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773E (31 December 2018); https://doi.org/10.1117/12.2324552

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