Tissue structural organization: measurement, interpretation, and modeling

Donald Duncan; David Fischer; Mehran Daneshbod; Scott Prahl

doi:10.1117/12.848962

23 February 2010 Tissue structural organization: measurement, interpretation, and modeling

Donald Duncan, David Fischer, Mehran Daneshbod, Scott Prahl

Proceedings Volume 7563, Dynamics and Fluctuations in Biomedical Photonics VII; 756304 (2010) https://doi.org/10.1117/12.848962
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Analysis of the first and second order statistical properties of light is a powerful means of establishing the properties of a medium with which the light has interacted. In turn, the first and second order statistical properties of the medium dictate the manner in which light interacts with the medium. The former is the inverse problem and the latter is the forward problem. Towards an understanding of the propagation of light through complex structures, such as biological tissue, one might choose to explore either the inverse or the forward problem. Fundamental to the problem, however, is a physical parametric model that relates the two halves; a model that allows prediction of the measured effect or prediction of the parameters based on measurements. This is the objective of our study. As a means of characterizing the first and second order properties of tissue, we discuss measurements with differential interference contrast microscopy using a phasestepping approach. First and second order properties are characterized respectively in terms of scatter phase functions and spatial power spectral densities. Results are shown for representative tissue.

Citation Download Citation

Donald Duncan, David Fischer, Mehran Daneshbod, and Scott Prahl "Tissue structural organization: measurement, interpretation, and modeling", Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 756304 (23 February 2010); https://doi.org/10.1117/12.848962

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