Liposomal particles are used as an instrument for drug delivery and as fluorescent labels. Due to its properties, liposomal particles can be used as a dual-purpose contrast agent both in fluorescence imaging, laser speckle contrast imaging and ultrasound diagnostics. Liposomes obtained by one purpose but subsequently contained a fluorescent label or air. This work aimed to prepare liposomal particles and to study possibilities of its application for the dual-use in fluorescence spectroscopy and ultrasound diagnostics. In this work, we used fluorescence spectroscopy to investigate the efficiency of propagation in the circulatory system of fluorescent-labelled liposome nanocapsules loaded with eosin-Y (disodium salt of 2,4,5,7 tetrabromofluorescein These results demonstrate that liposomal particles can be used in fluorescence spectroscopy, in ultrasound diagnostics and in LSCI. It may find the application in the field of drug delivery control and high-throughput screening during drug development.
The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes with polyethylene glycol (PEG) and without PEG when administered orally. Fluorescence channel with a fiber probe series of multifunctional laser non-invasive diagnostic system “LAKK-M” (SPE “LAZMA” Ltd, Russia) was used as the measuring equipment.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.