Prof. Alvin T. Yeh Profile

Prof. Alvin T. Yeh

Health Scientist Administrator at National Institutes of Health

SPIE Involvement:

Author

Publications (17)

Proceedings Article | 20 February 2020 Presentation + Paper

Compact spectrograph for hyperspectral imaging with overlapping fluorescent reporters

Nathan Hart, Holly Gibbs, Alvin Yeh

Proceedings Volume 11245, 112450L (2020) https://doi.org/10.1117/12.2546894

KEYWORDS: Prisms, Spectrographs, Monochromatic aberrations, Hyperspectral imaging, Distortion, Optical components, Microscopy, Freeform optics

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SPIE Journal Paper | 24 December 2014 Open Access

Combined lineage mapping and gene expression profiling of embryonic brain patterning using ultrashort pulse microscopy and image registration

Holly Gibbs, Colin Dodson, Yuqiang Bai, Arne Lekven, Alvin Yeh

JBO, Vol. 19, Issue 12, 126016, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.126016

KEYWORDS: Brain, Image registration, Tissues, Brain mapping, Atrial fibrillation, Optical lithography, Profiling, Neuroimaging, Microscopy, Luminescence

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SPIE Journal Paper | 19 March 2014 Open Access

Dynamic multicomponent engineered tissue reorganization and matrix deposition measured with an integrated nonlinear optical microscopy–optical coherence microscopy system

Yuqiang Bai, Po-Feng Lee, Holly Gibbs, Kayla Bayless, Alvin Yeh

JBO, Vol. 19, Issue 03, 036014, (March 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.3.036014

KEYWORDS: Collagen, Tissues, Optical fibers, Matrices, Second-harmonic generation, Tissue optics, Microscopy, Magnesium, Complex systems, Optical microscopy

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SPIE Journal Paper | 16 December 2013 Open Access

Imaging embryonic development with ultrashort pulse microscopy

Holly Gibbs, Yuqiang Bai, Arne Lekven, Alvin Yeh

OE, Vol. 53, Issue 05, 051506, (December 2013) https://doi.org/10.1117/12.10.1117/1.OE.53.5.051506

KEYWORDS: Ultrafast phenomena, Microscopy, Fluorescent proteins, Tissues, Image segmentation, Image resolution, Tissue optics, 3D image processing, Coherence (optics), Brain

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Proceedings Article | 26 March 2013 Paper

Combined lineage mapping and fate specification profiling with NLOM-OCM using sub-10-fs pulses

H. Gibbs, C. Dodson, Y. Bai, A. Lekven, A. Yeh

Proceedings Volume 8593, 85930K (2013) https://doi.org/10.1117/12.2004330

KEYWORDS: Tissues, Cerebellum, Profiling, Confocal microscopy, Imaging systems, Mirrors, Visualization, Luminescence, Image resolution, Reflectivity

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SPIE Journal Paper | 1 March 2013 Open Access

Time-lapse ultrashort pulse microscopy of infection in three-dimensional versus two-dimensional culture environments reveals enhanced extra-chromosomal virus replication compartment formation

Holly Gibbs, Garwin Sing, Juan Carlos Gonzalez Armas, Colin Campbell, Peter Ghazal, Alvin Yeh

JBO, Vol. 18, Issue 03, 031111, (March 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031111

KEYWORDS: Microscopy, Collagen, Ultrafast phenomena, 3D image processing, Time lapse microscopy, 3D modeling, Environmental sensing, Tissues, Binary data, Animal model studies

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SPIE Journal Paper | 2 March 2012 Open Access

Two-phoston excited fluorescence enhancement with broadband versus tunable femtosecond laser pulse excitation

Chao Wang, Alvin Yeh

JBO, Vol. 17, Issue 02, 025003, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.025003

KEYWORDS: Luminescence, Femtosecond phenomena, Pulsed laser operation, Absorption, Wavelength tuning, Spectrographs, Ultrafast phenomena, Tunable lasers, Sapphire lasers, Mode locking

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SPIE Journal Paper | 1 September 2010 Open Access

Molecular basis for optical clearing of collagenous tissues

Jason Hirshburg, Krishnakumar Ravikumar, Wonmuk Hwang, Alvin Yeh

JBO, Vol. 15, Issue 05, 055002, (September 2010) https://doi.org/10.1117/12.10.1117/1.3484748

KEYWORDS: Collagen, Optical clearing, Tissues, Skin, Hydrogen, Raman spectroscopy, Water, Carbon, Molecules

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SPIE Journal Paper | 1 September 2009 Open Access

Beyond the 1/Tp limit: two-photon-excited fluorescence using pulses as short as sub-10-fs

Shuo Pang, Alvin Yeh, Chao Wang, Kenith Meissner

JBO, Vol. 14, Issue 05, 054041, (September 2009) https://doi.org/10.1117/12.10.1117/1.3253388

KEYWORDS: Second-harmonic generation, Luminescence, Signal generators, Ultrafast phenomena, Solids, Absorption, Gaussian pulse, Pulsed laser operation, Microscopy, Tissues

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SPIE Journal Paper | 1 March 2008 Open Access

Special Section Guest Editorial: Optical Clearing of Tissues and Cells

Valery Tuchin, Alvin Yeh, Ruikang Wang

JBO, Vol. 13, Issue 02, 021101, (March 2008) https://doi.org/10.1117/12.10.1117/1.2903745

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Proceedings Article | 15 February 2008 Paper

Fiber delivery of sub-10-fs pulses for nonlinear optical microscopy

Adam Larson, Alvin Yeh

Proceedings Volume 6860, 68601R (2008) https://doi.org/10.1117/12.763321

KEYWORDS: Optical fibers, Dispersion, Single mode fibers, Imaging systems, Polarization, Fiber amplifiers, Image analysis, Optical microscopy, Microscopy, Fiber lasers

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SPIE Journal Paper | 1 July 2006 Open Access

Collagen solubility correlates with skin optical clearing

Jason Hirshburg, Bernard Choi, J. Nelson, Alvin Yeh

JBO, Vol. 11, Issue 04, 040501, (July 2006) https://doi.org/10.1117/12.10.1117/1.2220527

KEYWORDS: Collagen, Skin, Tissue optics, Optical clearing, Chemical analysis, Scattering, Tissues, Refractive index, Light scattering, In vitro testing

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Proceedings Article | 23 February 2006 Paper

Surface enhanced Raman spectroscopy (SERS) for the detection of intracellular constituents using gold nanoshells

Mustafa Chowdhury, Colin Campbell, Eirini Theofanidou, Seung Joon Lee, Angela Baldwin, Garwin Sing, Alvin Yeh, Jason Crain, Peter Ghazal, Gerard Coté

Proceedings Volume 6099, 609905 (2006) https://doi.org/10.1117/12.646464

KEYWORDS: Surface enhanced Raman spectroscopy, Gold, Raman spectroscopy, Water, Metals, Nanoparticles, Transmission electron microscopy, Silica, Microscopy, Dielectrics

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SPIE Journal Paper | 1 January 2006 Open Access

Molecular interactions of exogenous chemical agents with collagen—implications for tissue optical clearing

Alvin Yeh, Jason Hirshburg

JBO, Vol. 11, Issue 01, 014003, (January 2006) https://doi.org/10.1117/12.10.1117/1.2166381

KEYWORDS: Collagen, Tissue optics, Optical clearing, Tissues, Molecular interactions, Second-harmonic generation, Skin, Scattering, Hydrogen, Laser therapeutics

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Proceedings Article | 13 July 2004 Open Access

Multiphoton imaging of excised normal skin and keloid scar: preliminary investigations

Michael Brewer, Alvin Yeh, Behrooz Torkian, Chung-Ho Sun, Bruce Tromberg, Brian Wong

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.543540

KEYWORDS: Tissues, Collagen, Skin, Tumors, Multiphoton microscopy, Wound healing, Luminescence, Surgery, Laser tissue interaction, Injuries

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SPIE Journal Paper | 1 March 2004 Open Access

Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model

Alvin Yeh, Bunsho Kao, Woong Jung, Zhongping Chen, John Nelson, Bruce Tromberg

JBO, Vol. 9, Issue 02, (March 2004) https://doi.org/10.1117/12.10.1117/1.1648646

KEYWORDS: Collagen, Optical coherence tomography, Second-harmonic generation, Tissue optics, Wound healing, Injuries, Tissues, Luminescence, Light scattering, Linear filtering

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Proceedings Article | 17 June 2002 Open Access

Combined two-photon excited fluorescence and second-harmonic generation backscattering microscopy of turbid tissues

Aikaterini Zoumi, Alvin Yeh, Bruce Tromberg

Proceedings Volume 4620, (2002) https://doi.org/10.1117/12.470701

KEYWORDS: Second-harmonic generation, Collagen, Tissues, Luminescence, Bandpass filters, Optical filters, Image filtering, Visualization, Backscatter, Microscopy

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